Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP6V1B1 | P15313 | 5/20 | 0.64 |
| ▸ | ATP6AP1 | Q15904 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.31 |
| ▸ | KLK7 | P49862 | 1/20 | 0.31 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2400954 | 1.00 | ATP6V1B1 (0.64) | ATP6V1B1ATP6AP1HDAC4HDAC6KDM4E | |
| SCHEMBL2400959 | 1.00 | ATP6V1B1 (0.64) | ATP6V1B1ATP6AP1HDAC4HDAC6KDM4E | |
| SCHEMBL1229728 | 0.90 | ATP6V1B1 (0.80) | ATP6V1B1ATP6AP1HDAC4HDAC6 | |
| SCHEMBL1229725 | 0.90 | ATP6V1B1 (0.80) | ATP6V1B1ATP6AP1HDAC4HDAC6 | |
| SCHEMBL29546820 | 0.90 | ATP6V1B1 (0.80) | ATP6V1B1ATP6AP1HDAC4HDAC6 | |
| SCHEMBL6296395 | 0.90 | ATP6V1B1 (0.80) | ATP6V1B1ATP6AP1HDAC4HDAC6 | |
| SCHEMBL6296361 | 0.90 | ATP6V1B1 (0.80) | ATP6V1B1ATP6AP1HDAC4HDAC6 | |
| SCHEMBL1229727 | 0.90 | ATP6V1B1 (0.80) | ATP6V1B1ATP6AP1HDAC4HDAC6 | |
| SCHEMBL6291989 | 0.87 | ATP6V1B1 (0.60) | ATP6V1B1ATP6AP1HDAC4HDAC6MAPT | |
| SCHEMBL6291994 | 0.87 | ATP6V1B1 (0.60) | ATP6V1B1ATP6AP1HDAC4HDAC6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110237497-A1 | COMPOSITIONS OF A V-ATPASE INHIBITOR IN COMBINATION WITH A GLUCOCORTICOID RECEPTOR LIGAND AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-09-29 | — | — | US | disclosed |
| US-20110237497-A1 | COMPOSITIONS OF A V-ATPASE INHIBITOR IN COMBINATION WITH A GLUCOCORTICOID RECEPTOR LIGAND AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-09-29 | — | — | US | disclosed |
| US-20110237497-A1 | COMPOSITIONS OF A V-ATPASE INHIBITOR IN COMBINATION WITH A GLUCOCORTICOID RECEPTOR LIGAND AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237497-A1 | COMPOSITIONS OF A V-ATPASE INHIBITOR IN COMBINATION WITH A GLUCOCORTICOID RECEPTOR LIGAND AND METHODS OF USE | ATP6V1G1, ATP6V1E1, NR3C1 | ATP6V1B1 22/4885ATP6AP1 6/4885HDAC4 304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.