Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diclofenac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 8/20 | 0.97 |
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.97 |
| ▸ | CXCL8 | P10145 | 4/20 | 0.97 |
| ▸ | TTR | P02766 | 3/20 | 0.97 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.97 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.97 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.97 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.97 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.97 |
| ▸ | ALB | P02768 | 1/20 | 0.97 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.97 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.97 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.97 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.97 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.97 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.97 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.97 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.97 |
| ▸ | UGT1A10 | Q9HAW8 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diclofenac SCHEMBL9406452 | 1.00 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL6509236 | 0.98 | PTGS2 (0.94) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL996716 | 0.98 | PTGS2 (1.00) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL2799 | 0.98 | PTGS2 (1.00) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL29354260 | 0.98 | PTGS2 (1.00) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL1231246 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL1178502 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL22129258 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL22370200 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL418230 | 0.97 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 33218 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122075390-A | Preparation and application of novel cow uterus injectant | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075220-A | Contact lens for treating xerophthalmia and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-121197040-B | In-situ carrier hydrogel based on nano bottle packaging technology and preparation method and application thereof | 上海大学 | 2026-05-19 | — | — | CN | claimed |
| CN-122031445-A | External pharmaceutical composition containing loxoprofen | 第一三共健康事业株式会社 | 2026-05-15 | — | — | CN | claimed |
| CN-122031290-A | Percutaneous permeation promoting system and preparation method and application thereof | 北京工商大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122032567-A | Cobalt-doped cerium oxide spherical nanocluster catalyst and preparation method and application thereof | 华南师范大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122031449-A | External pharmaceutical composition containing loxoprofen and diclofenac | 第一三共健康事业株式会社 | 2026-05-15 | — | — | CN | claimed |
| US-20260130853-A1 | METHOD OF TREATING GOUT BY TOPICAL APPLICATION OF NANO LINIMENT | Zhang, Boke (US) | 2026-05-14 | — | — | US | claimed |
| US-20260130854-A1 | PREPARATION OF NANO LINIMENT FOR EXTERNAL TREATMENT OF GOUT | Zhang, Boke (US) | 2026-05-14 | — | — | US | claimed |
| CN-122005440-A | Externally applied preparation for treating meniscus sports injury and preparation method thereof | 高溢 | 2026-05-12 | — | — | CN | claimed |
| US-4472376-A | ABSORPTION OF MIXTURE OF CARBOXYVINYL POLYMER, BASE, AND ACTIVE MATERIAL INTO BLOOD | TOKO YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1984-09-18 | — | — | US | claimed |
| US-4455298-A | MOLLUSC EXTRACT | MCFARLANE STUART J (NZ) | 1984-06-19 | — | — | US | claimed |
| US-4455146-A | THERMOPLASTIC ELASTOMERS, OILS OR FATTY ACID, TACKFIER, AND A MEDICINE | HISAMITSU PHARMACEUTICAL CO., LTD. (JP) | 1984-06-19 | — | — | US | claimed |
| EP-0004040-B1 | PHARMACEUTICAL COMPOSITIONS HAVING ANALGESIC PROPERTIES COMPRISING A COMPOUND SELECTED FROM D- AND DL-PHENYLALANINE, D- AND DL-LEUCINE AND HYDROCINNAMIC ACID IN THE UNIT DOSE OF AT LEAST 200MG | MERCK PATENT GmbH (DE) | 1983-10-05 | — | — | EP | claimed |
| EP-0010061-B1 | PHARMACEUTICAL PREPARATIONS CONTAINING A MOLLUSC EXTRACT | Mc Farlane, Stuart John (NZ) | 1983-07-13 | — | — | EP | claimed |
| EP-0017169-B1 | IMPROVED ANTI-INFLAMMATORY COMBINATIONS HAVING REDUCED ULCEROGENICITY | MERCK & CO. INC. (US) | 1983-03-09 | — | — | EP | claimed |
| EP-0017169-A1 | Improved anti-inflammatory combinations having reduced ulcerogenicity | MERCK & CO. INC. (US) | 1980-10-15 | — | — | EP | claimed |
| WO-1980000661-A1 | PHARMACEUTICAL PREPARATIONS | CROFT J (NZ) | 1980-04-17 | — | — | WO | claimed |
| EP-0010061-A1 | Pharmaceutical preparations containing a mollusc extract | Mc Farlane, Stuart John (NZ) | 1980-04-16 | — | — | EP | claimed |
| EP-0004040-A1 | Pharmaceutical compositions having analgesic properties comprising a compound selected from D- and DL-phenylalanine, D- and DL-leucine and hydrocinnamic acid in the unit dose of at least 200mg | MERCK PATENT GmbH (DE) | 1979-09-19 | — | — | EP | claimed |