Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | FASN | P49327 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12540389 | 1.00 | ALDH1A1 (0.38) | ALDH1A1LMNAL3MBTL1BTKSMN1; SMN2 | |
| SCHEMBL482252 | 0.91 | LMNA (0.40) | ALDH1A1LMNAL3MBTL1SMN1; SMN2POLB | |
| SCHEMBL3209818 | 0.91 | LMNA (0.40) | ALDH1A1LMNAL3MBTL1SMN1; SMN2POLB | |
| SCHEMBL12814495 | 0.83 | LMNA (0.36) | ALDH1A1LMNABTKSMN1; SMN2KMT2A | |
| SCHEMBL12540850 | 0.83 | LMNA (0.36) | ALDH1A1LMNABTKSMN1; SMN2KMT2A | |
| SCHEMBL5657066 | 0.79 | CHRNB2 (0.41) | ALDH1A1L3MBTL1BTKSMN1; SMN2POLB | |
| SCHEMBL5660203 | 0.79 | CHRNB2 (0.41) | ALDH1A1L3MBTL1BTKSMN1; SMN2POLB | |
| SCHEMBL1811527 | 0.79 | BTK (0.37) | ALDH1A1LMNABTKPOLBEPHX2 | |
| SCHEMBL103478 | 0.78 | POLB (0.47) | ALDH1A1LMNAL3MBTL1SMN1; SMN2POLB | |
| SCHEMBL20939108 | 0.78 | L3MBTL1 (0.39) | ALDH1A1LMNAL3MBTL1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150272947-A1 | INHIBITORS OF PROTEIN KINASES | ASTRAZENECA AB (SE) | 2015-10-01 | — | — | US | disclosed |
| US-20110224225-A1 | Inhibitors of protein kinases | ASTRAZENECA AB (SE) | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150272947-A1 | INHIBITORS OF PROTEIN KINASES | CDK1, CDK2, CDK3 | ALDH1A1 2914/4885LMNA 1506/4885L3MBTL1 2099/4885 |
| US-20110224225-A1 | Inhibitors of protein kinases | CDK1, CDK2, CDK3 | ALDH1A1 2914/4885LMNA 1506/4885L3MBTL1 2099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.