Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | PPID | Q08752 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24011472 | 0.94 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL26633709 | 0.90 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011598 | 0.86 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011343 | 0.85 | LMNA (0.55) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL26633877 | 0.84 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011344 | 0.83 | RAB9A (0.61) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011596 | 0.83 | RAB9A (0.58) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011431 | 0.82 | RAB9A (0.61) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011342 | 0.81 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 | |
| SCHEMBL24011546 | 0.80 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2MCHR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230348369-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-11-02 | — | — | US | disclosed |
| WO-2021226276-A2 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348369-A1 | NAMPT MODULATORS | NAMPT, NNT, NAPRT | NPC1 128/4885RAB9A 814/4885SMN1; SMN2 610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.