Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | VNN1 | O95497 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24016536 | 0.91 | LMNA (0.50) | ALDH1A1LMNASORT1SMN1; SMN2EPHX2 | |
| SCHEMBL24016565 | 0.86 | MEN1 (0.55) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL24016253 | 0.85 | PPARG (0.53) | MEN1KMT2AALDH1A1LMNAHTT | |
| SCHEMBL24016185 | 0.85 | TEAD1 (0.63) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL24016596 | 0.85 | TEAD1 (0.43) | ALDH1A1MAPTLMNANAMPTKDM4E | |
| SCHEMBL24016598 | 0.84 | TEAD1 (0.44) | ALDH1A1MAPTLMNANAMPTDGAT2 | |
| SCHEMBL30561352 | 0.83 | ALDH1A1 (0.56) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL25381780 | 0.83 | ALDH1A1 (0.56) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL24016579 | 0.83 | TEAD1 (0.48) | MAPT | |
| SCHEMBL24016071 | 0.82 | TEAD1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021224291-A1 | TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS | MERCK PATENT GMBH (DE) | 2021-11-11 | — | — | WO | disclosed |