Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22957766 | 0.84 | RIPK1 (0.55) | RIPK1ALDH1A1MCHR1HTR2CSLC6A2 | |
| SCHEMBL22957805 | 0.83 | RIPK1 (0.54) | RIPK1ALDH1A1MCHR1HTR2CFAAH | |
| SCHEMBL29786424 | 0.82 | RIPK1 (0.55) | RIPK1MCHR1HTR2CFAAHCNR1 | |
| SCHEMBL20472415 | 0.82 | RIPK1 (0.55) | RIPK1MCHR1HTR2CFAAHCNR1 | |
| SCHEMBL22957672 | 0.82 | RIPK1 (0.60) | RIPK1MAPTMCHR1HTR2CFAAH | |
| SCHEMBL22957773 | 0.81 | RIPK1 (0.55) | RIPK1ALDH1A1MCHR1HTR2CSLC6A2 | |
| SCHEMBL20472353 | 0.81 | RIPK1 (0.54) | RIPK1MCHR1HTR2CFAAHCNR1 | |
| SCHEMBL29786709 | 0.81 | RIPK1 (0.54) | RIPK1MCHR1HTR2CFAAHCNR1 | |
| SCHEMBL22957804 | 0.81 | RIPK1 (0.51) | RIPK1MCHR1FAAHCNR1CNR2 | |
| SCHEMBL22957816 | 0.79 | RIPK1 (0.60) | RIPK1MAPTMCHR1HTR2CSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3580220-B1 | AMINOTRIAZOLOPYRIDINES AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-11-17 | — | — | EP | disclosed |