Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22957672 | 0.97 | RIPK1 (0.60) | RIPK1HTTHTR2CNPY1RNPY2R | |
| SCHEMBL22957658 | 0.94 | RIPK1 (0.68) | RIPK1HTTHTR2CNPY1RNPY2R | |
| SCHEMBL22957773 | 0.85 | RIPK1 (0.55) | RIPK1HTR2CMCHR1HPGDSLC6A2 | |
| SCHEMBL22957661 | 0.83 | RIPK1 (0.61) | RIPK1HTTHTR2CMEN1CYP1A2 | |
| SCHEMBL22391548 | 0.82 | RIPK1 (0.88) | RIPK1HTR2CMCHR1P2RX4MEN1 | |
| SCHEMBL22957766 | 0.82 | RIPK1 (0.55) | RIPK1HTR2CMCHR1SLC6A2SLC6A4 | |
| SCHEMBL22957853 | 0.81 | NPY1R (0.49) | RIPK1HTTHTR2CNPY1RNPY2R | |
| SCHEMBL22957805 | 0.81 | RIPK1 (0.54) | RIPK1HTR2CMCHR1SLC6A2SLC6A4 | |
| SCHEMBL24018785 | 0.79 | RIPK1 (0.51) | RIPK1HTR2CMCHR1P2RX4MAPT | |
| SCHEMBL22390530 | 0.79 | RIPK1 (0.88) | RIPK1HTR2CMCHR1MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10913738-B2 | Aminotriazolopyridines as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10913738-B2 | Aminotriazolopyridines as kinase inhibitors | RIPK1, RIPK3, RIPK4 | RIPK1 1/4885HTT 4152/4885HTR2C 3116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.