Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22957816 | 0.97 | RIPK1 (0.60) | RIPK1HTTNPY1RNPY2RHTR2C | |
| SCHEMBL22957658 | 0.94 | RIPK1 (0.68) | RIPK1HTTNPY1RNPY2RHTR2C | |
| SCHEMBL22957766 | 0.85 | RIPK1 (0.55) | RIPK1HTR2CSLC6A2SLC6A4KCNH2 | |
| SCHEMBL22957805 | 0.84 | RIPK1 (0.54) | RIPK1HTR2CSLC6A2SLC6A4KCNH2 | |
| SCHEMBL22957853 | 0.83 | NPY1R (0.49) | RIPK1HTTNPY1RNPY2RHTR2C | |
| SCHEMBL22957661 | 0.83 | RIPK1 (0.61) | RIPK1HTTHTR2CCYP1A2CYP2D6 | |
| SCHEMBL24018785 | 0.82 | RIPK1 (0.51) | RIPK1HTR2CSLC6A2SLC6A4KCNH2 | |
| SCHEMBL22390530 | 0.82 | RIPK1 (0.88) | RIPK1HTR2CCYP1A2CYP2D6ADRA1A | |
| SCHEMBL22957773 | 0.82 | RIPK1 (0.55) | RIPK1HTR2CSLC6A2SLC6A4KCNH2 | |
| SCHEMBL22957804 | 0.81 | RIPK1 (0.51) | RIPK1MCHR1FAAHCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10913738-B2 | Aminotriazolopyridines as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10913738-B2 | Aminotriazolopyridines as kinase inhibitors | RIPK1, RIPK3, RIPK4 | RIPK1 1/4885HTT 4152/4885NPY1R 2919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.