Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.77 |
| ▸ | MAPT | P10636 | 5/20 | 0.77 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.68 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.68 |
| ▸ | FLT3 | P36888 | 5/20 | 0.60 |
| ▸ | PYGL | P06737 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8176164 | 0.89 | KDM4E (0.66) | KDM4EALDH1A1MAPTPDGFRBPDGFRA | |
| SCHEMBL17149703 | 0.86 | KDM4E (0.66) | KDM4EALDH1A1MAPTPDGFRBPDGFRA | |
| SCHEMBL9517979 | 0.85 | PDGFRB (0.72) | KDM4EALDH1A1MAPTPDGFRBPDGFRA | |
| SCHEMBL19352730 | 0.84 | KDM4E (0.64) | KDM4EALDH1A1MAPTPDGFRBPDGFRA | |
| SCHEMBL22518517 | 0.84 | PDGFRB (0.70) | KDM4EALDH1A1MAPTPDGFRBPDGFRA | |
| SCHEMBL19352890 | 0.83 | PYGL (0.64) | KDM4EALDH1A1MAPTPDGFRBPDGFRA | |
| SCHEMBL8176165 | 0.82 | PDGFRB (0.56) | KDM4EALDH1A1MAPTPDGFRBPDGFRA | |
| SCHEMBL17321403 | 0.82 | PDGFRB (0.72) | KDM4EALDH1A1MAPTPDGFRBPDGFRA | |
| SCHEMBL14845690 | 0.82 | PIN1 (0.62) | KDM4EALDH1A1MAPTPDGFRBPDGFRA | |
| SCHEMBL2735968 | 0.82 | FLT3 (0.61) | KDM4EALDH1A1MAPTPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212152-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. | 2023-07-06 | — | — | US | disclosed |
| US-20230212152-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. | 2023-07-06 | — | — | US | disclosed |
| US-11524940-B1 | Inhibitors of cysteine proteases and methods of use thereof | Pardes Biosciences, Inc. (US) | 2022-12-13 | — | — | US | disclosed |
| US-11174231-B1 | Inhibitors of cysteine proteases and methods of use thereof | Pardes Biosciences, Inc. (US) | 2021-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11174231-B1 | Inhibitors of cysteine proteases and methods of use thereof | CTRL, CTSV, CTSL | KDM4E 2930/4885ALDH1A1 2252/4885MAPT 1905/4885 |
| US-11524940-B1 | Inhibitors of cysteine proteases and methods of use thereof | CTRL, CTSV, CTSL | KDM4E 2930/4885ALDH1A1 2252/4885MAPT 1905/4885 |
| US-20230212152-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | CTRL, CTSL, CTSV | KDM4E 3122/4885ALDH1A1 1863/4885MAPT 2314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.