SCHEMBL2402648

SCHEMBL2402648

CN1CCC[C@H]1CCC1c2cc(S(N)(=O)=O)ccc2CCN1CC1CCCCC1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 5/20 0.36
CA9 Q16790 3/20 0.36
CA12 O43570 3/20 0.36
CA1 P00915 3/20 0.36
CA7 P43166 3/20 0.36
DRD2 P14416 2/20 0.36
DRD1 P21728 2/20 0.36
DRD4 P21917 2/20 0.36
DRD3 P35462 2/20 0.36
CYP1A2 P05177 2/20 0.36
CYP2D6 P10635 2/20 0.36
CA3 P07451 1/20 0.36
ADRA2A P08913 1/20 0.36
MAPT P10636 1/20 0.36
PTGS1 P23219 1/20 0.36
CA6 P23280 1/20 0.36
CA5A P35218 1/20 0.36
BLM P54132 1/20 0.36
CA5B Q9Y2D0 1/20 0.36
LMNA P02545 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fumaric Acid SCHEMBL2404085 0.92 LMNA (0.36) CA2CA9CA12CA1CA7
Hydrochloric Acid SCHEMBL2526832 0.85 TSHR (0.36) CA2CA9CA12CA1CA7
SCHEMBL2406236 0.79 CA2 (0.44) CA2CA9CA12CA1CA7
SCHEMBL2405712 0.76 HTR7 (0.40) CA2CA9CA12CA1CA7
SCHEMBL2402408 0.76 HTR7 (0.40) CA2CA9CA12CA1CA7
Hydrochloric Acid SCHEMBL14686044 0.75 HTR7 (0.39) CA2CA9CA12CA1CA7
SCHEMBL3553406 0.69 HRH3 (0.44) HRH3KCNH2HRH1
SCHEMBL2400927 0.68 HRH3 (0.46) TSHRHRH3
SCHEMBL1241268 0.68 HRH3 (0.46) TSHRHRH3
Water SCHEMBL16161850 0.67 HRH3 (0.46) TSHRHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2556064-A2 PROCESS FOR THE PREPARATION OF 2-(CYCLOHEXYLMETHYL)-N-{2- [(2S)-1-METHYLPYRROLIDIN-2-YL]ETHYL}-1, 2, 3, 4- TETRAHYDROISOQUINOLINE-7-SULFONAMIDE SANOFI (FR) 2013-02-13 EP claimed
EP-2542530-A2 PROCESS FOR THE PREPARATION OF 2-(CYCLOHEXYLMETHYL)-N-{2- [(2S)-1-METHYLPYRROLIDIN-2-YL]ETHYL}-1, 2, 3, 4- TETRAHYDROISOQUINOLINE-7-SULFONAMIDE SANOFI (FR) 2013-01-09 EP claimed
WO-2011109680-A2 PROCESS FOR THE PREPARATION OF 2-(CYCLOHEXYLMETHYL)-N-{2- [(2S)-1-METHYLPYRROLIDIN-2-YL]ETHYL}-1, 2, 3, 4- TETRAHYDROISOQUINOLINE-7-SULFONAMIDE SANOFI (FR) 2011-09-09 WO claimed
WO-2011109675-A2 PROCESS FOR THE PREPARATION OF 2-(CYCLOHEXYLMETHYL)-N-{2- [(2S)-1-METHYLPYRROLIDIN-2-YL]ETHYL}-1, 2, 3, 4- TETRAHYDROISOQUINOLINE-7-SULFONAMIDE SANOFI (FR) 2011-09-09 WO claimed
EP-3043799-A1 AN H3 RECEPTOR ANTAGONIST COMBINED WITH A CHOLINESTERASE INHIBITOR FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE SANOFI (FR) 2016-07-20 EP disclosed
WO-2015032966-A1 AN H3 RECEPTOR ANTAGONIST COMBINED WITH A CHOLINESTERASE INHIBITOR FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE SANOFI (FR) 2015-03-12 WO disclosed
CN-103068815-A Process for the preparation of 2-(cyclohexylmethyl)-n-{2- [(2s)-1-methylpyrrolidin-2-yl]ethyl}-1, 2, 3, 4- tetrahydroisoquinoline-7-sulfonamide SANOFI SA 2013-04-24 CN disclosed
EP-2556064-A2 PROCESS FOR THE PREPARATION OF 2-(CYCLOHEXYLMETHYL)-N-{2- [(2S)-1-METHYLPYRROLIDIN-2-YL]ETHYL}-1, 2, 3, 4- TETRAHYDROISOQUINOLINE-7-SULFONAMIDE SANOFI (FR) 2013-02-13 EP disclosed
EP-2542530-A2 PROCESS FOR THE PREPARATION OF 2-(CYCLOHEXYLMETHYL)-N-{2- [(2S)-1-METHYLPYRROLIDIN-2-YL]ETHYL}-1, 2, 3, 4- TETRAHYDROISOQUINOLINE-7-SULFONAMIDE SANOFI (FR) 2013-01-09 EP disclosed
WO-2011109680-A2 PROCESS FOR THE PREPARATION OF 2-(CYCLOHEXYLMETHYL)-N-{2- [(2S)-1-METHYLPYRROLIDIN-2-YL]ETHYL}-1, 2, 3, 4- TETRAHYDROISOQUINOLINE-7-SULFONAMIDE SANOFI (FR) 2011-09-09 WO disclosed
WO-2011109675-A2 PROCESS FOR THE PREPARATION OF 2-(CYCLOHEXYLMETHYL)-N-{2- [(2S)-1-METHYLPYRROLIDIN-2-YL]ETHYL}-1, 2, 3, 4- TETRAHYDROISOQUINOLINE-7-SULFONAMIDE SANOFI (FR) 2011-09-09 WO disclosed