Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30071336 | 0.86 | ALDH1A1 (0.48) | KDM4EHPGDSMN1; SMN2MAPK1HTT | |
| SCHEMBL12199271 | 0.77 | CCNE2 (0.44) | KDM4EHPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL11542523 | 0.72 | ALDH1A1 (0.44) | KDM4EHPGDSMN1; SMN2GAATP53 | |
| SCHEMBL11537754 | 0.71 | ALDH1A1 (0.45) | KDM4EHPGDSMN1; SMN2GAAMAPK1 | |
| SCHEMBL21782902 | 0.70 | SMN1; SMN2 (0.59) | KDM4EHPGDSMN1; SMN2GAATP53 | |
| SCHEMBL11536470 | 0.70 | CYP2C19 (0.44) | KDM4EHPGDSMN1; SMN2HTTTP53 | |
| SCHEMBL1850645 | 0.68 | MAPT (0.56) | SMN1; SMN2GAAMAPK1TP53RAB9A | |
| SCHEMBL4112089 | 0.68 | ALDH1A1 (0.68) | SMN1; SMN2GAAHTTRAB9ANPC1 | |
| SCHEMBL5837409 | 0.67 | SMN1; SMN2 (0.58) | SMN1; SMN2GAAHTTTP53RAB9A | |
| SCHEMBL1852828 | 0.67 | RAB9A (0.64) | KDM4ESMN1; SMN2GAAMAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021231778-A1 | CORONAVIRUS PROTEASE DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-11-18 | — | — | WO | disclosed |