Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 11/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25625467 | 0.85 | POLB (0.39) | POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25625198 | 0.84 | AKT1 (0.40) | KCNN4POLBMEN1KMT2A | |
| SCHEMBL24036745 | 0.83 | PDE2A (0.36) | PDE2AAPPKCNN4POLBMEN1 | |
| SCHEMBL25625541 | 0.82 | GPR139 (0.46) | PDE2A | |
| Hydrochloric Acid SCHEMBL7171364 | 0.81 | ALDH1A1 (0.46) | PDE2APOLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25752924 | 0.81 | PDE2A (0.44) | PDE2AAPPKCNN4CTSD | |
| Hydrochloric Acid SCHEMBL7173937 | 0.81 | GPR139 (0.45) | PDE2A | |
| SCHEMBL24036949 | 0.80 | RIPK1 (0.40) | PDE2AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25623348 | 0.78 | APP (0.38) | PDE2AAPPKCNN4 | |
| SCHEMBL25753659 | 0.78 | APP (0.38) | PDE2AAPPKCNN4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192661-A1 | 1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE | UBE CORPORATION (JP) | 2023-06-22 | — | — | US | disclosed |
| WO-2023085396-A1 | PHARMACEUTICAL COMPOSITION FOR PROVIDING TREATMENT FOR OR PREVENTING ALPORT SYNDROME | ＵＢＥ株式会社 | 2023-05-19 | — | — | WO | disclosed |
| WO-2021230325-A1 | 1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE | 宇部興産株式会社 | 2021-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192661-A1 | 1, 4, 5, 6-TETRAHYDROPYRIMIDINE-2-AMINE DERIVATIVE | DHFR, DPYD, CYP2D6 | PDE2A 2400/4885APP 4211/4885KCNN4 2255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.