Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26278104 | 0.81 | KEAP1 (0.38) | MAOAMAOBDHODHHAVCR2ALDH1A1 | |
| SCHEMBL23148027 | 0.76 | GRIN1 (0.44) | ALDH1A1GAAKDM4EHPGDLMNA | |
| SCHEMBL30265966 | 0.76 | GAA (0.46) | MAOAMAOBALDH1A1GAAKDM4E | |
| SCHEMBL5729594 | 0.76 | GAA (0.46) | MAOAMAOBALDH1A1GAAKDM4E | |
| SCHEMBL19624741 | 0.75 | NPC1 (0.38) | MAOAMAOBGAAKDM4ENPC1 | |
| SCHEMBL29104141 | 0.74 | PRKCQ (0.44) | MAOAMAOBHAVCR2KDM4EPDE3B | |
| SCHEMBL3267277 | 0.73 | RXFP1 (0.44) | ALDH1A1GAAKDM4ERXFP1MAPT | |
| SCHEMBL1484857 | 0.72 | IMPDH2 (0.42) | MAOAMAOBDHODHPRKCQPRKCD | |
| SCHEMBL23147759 | 0.71 | KDM4E (0.50) | ALDH1A1GAAKDM4ERXFP1MAPT | |
| SCHEMBL29813016 | 0.71 | KDM4E (0.50) | ALDH1A1GAAKDM4ERXFP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021229302-A1 | SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2021-11-18 | — | — | WO | disclosed |