Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 8/20 | 0.43 |
| ▸ | GNAO1 | P09471 | 8/20 | 0.43 |
| ▸ | GNAI1 | P63096 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21024634 | 0.98 | GNAI3 (0.42) | GNAI3GNAO1GNAI1KDM4EUSP2 | |
| SCHEMBL24345186 | 0.90 | GNAI3 (0.41) | GNAI3GNAO1GNAI1GPR84FFAR1 | |
| SCHEMBL20372808 | 0.90 | ALDH1A1 (0.39) | GNAI3GNAO1GNAI1KDM4EUSP2 | |
| SCHEMBL24398569 | 0.88 | GPR84 (0.41) | GPR84FFAR1 | |
| SCHEMBL26465066 | 0.80 | GAA (0.46) | GNAI3GNAO1GNAI1KDM4EALDH1A1 | |
| SCHEMBL20626619 | 0.79 | DPP4 (0.41) | — | |
| SCHEMBL22363328 | 0.78 | PIK3CD (0.41) | GNAI3GNAO1GNAI1KDM4EUSP2 | |
| SCHEMBL14696390 | 0.78 | LMNA (0.41) | — | |
| SCHEMBL22622606 | 0.77 | PIK3CD (0.43) | — | |
| SCHEMBL23867052 | 0.77 | GNAI3 (0.50) | GNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11180474-B2 | Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11180474-B2 | Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors | TLR9, TLR7, TLR8 | GNAI3 283/4885GNAO1 527/4885GNAI1 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.