Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 7/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | BPTF | Q12830 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22295927 | 0.82 | RAB9A (0.47) | NPC1RAB9ATP53SMN1; SMN2PKM | |
| SCHEMBL1752770 | 0.79 | MAPT (0.47) | NPC1RAB9AUSP2TP53SMN1; SMN2 | |
| SCHEMBL2493590 | 0.79 | RAB9A (0.62) | NPC1RAB9AUSP2TP53SMN1; SMN2 | |
| SCHEMBL21017428 | 0.79 | NPC1 (0.47) | NPC1RAB9AUSP2TP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3592354 | 0.78 | MAPT (0.46) | NPC1RAB9AUSP2TP53SMN1; SMN2 | |
| SCHEMBL1752922 | 0.78 | RAB9A (0.62) | NPC1RAB9AUSP2TP53SMN1; SMN2 | |
| SCHEMBL19521326 | 0.76 | TYK2 (0.45) | SMN1; SMN2 | |
| SCHEMBL29494637 | 0.76 | TYK2 (0.45) | SMN1; SMN2 | |
| SCHEMBL19153613 | 0.75 | KDM4E (0.67) | NPC1RAB9ATP53SMN1; SMN2PKM | |
| SCHEMBL20312702 | 0.75 | ACHE (0.43) | NPC1RAB9AUSP2TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0225886-B1 | NEW PYRIDAZINE COMPOSITIONS, PRODUCTION PROCESS THEREOF AND FUNGICIDES AND ALGICIDES CONTAINING THEM | AGROLINZ AGRARCHEMIKALIEN GESELLSCHAFT M.B.H. (AT) | 1990-06-20 | — | — | EP | claimed |
| EP-0225886-A1 | NEW PYRIDAZINE COMPOSITIONS, PRODUCTION PROCESS THEREOF AND FUNGICIDES AND ALGICIDES CONTAINING THEM. | CHEMIE LINZ AG (AT) | 1987-06-24 | — | — | EP | claimed |
| WO-1986006719-A1 | NEW PYRIDAZINE COMPOSITIONS, PRODUCTION PROCESS THEREOF AND FUNGICIDES AND ALGICIDES CONTAINING THEM | CHEMIE LINZ AKTIENGESELLSCHAFT (AT) | 1986-11-20 | — | — | WO | claimed |
| US-11535597-B2 | Photoreactive ligands and uses thereof | THE SCRIPPS RESEARCH INSTITUTE (US) | 2022-12-27 | — | — | US | disclosed |
| US-20200071277-A1 | PHOTOREACTIVE LIGANDS AND USES THEREOF | THE SCRIPPS RESEARCH INSTITUTE | 2020-03-05 | — | — | US | disclosed |
| US-9242961-B2 | Aurora kinase modulators and method of use | AMGEN INC. (US) | 2016-01-26 | — | — | US | disclosed |
| US-20140066430-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2014-03-06 | — | — | US | disclosed |
| US-20120245125-A1 | PYRIDAZINE COMPOUNDS, COMPOSITIONS AND METHODS | UNIVERSITE LOUIS PASTEUR DE STRASBOURG (FR) | 2012-09-27 | — | — | US | disclosed |
| US-20110263530-A1 | Aurora Kinase Modulators and Method of Use | AMGEN INC. (US) | 2011-10-27 | — | — | US | disclosed |
| US-8022221-B2 | Aurora kinase modulators and method of use | AMGEN INC. (US) | 2011-09-20 | — | — | US | disclosed |
| US-7560551-B2 | Aurora kinase modulators and method of use | AMGEN INC. (US) | 2009-07-14 | — | — | US | disclosed |
| EP-1325910-B1 | ALIPHATIC NITROGENOUS FIVE-MEMBERED RING COMPOUNDS | MITSUBISHI TANABE PHARMA CORP (JP) | 2008-09-17 | — | — | EP | disclosed |
| US-20070185111-A1 | Aurora kinase modulators and method of use | AMGEN INC. | 2007-08-09 | — | — | US | disclosed |
| US-7160877-B2 | Aliphatic nitrogen-containing 5-membered ring compound | TANABE SEIYAKU CO., LTD. (JP) | 2007-01-09 | — | — | US | disclosed |
| EP-0225886-B1 | NEW PYRIDAZINE COMPOSITIONS, PRODUCTION PROCESS THEREOF AND FUNGICIDES AND ALGICIDES CONTAINING THEM | AGROLINZ AGRARCHEMIKALIEN GESELLSCHAFT M.B.H. (AT) | 1990-06-20 | — | — | EP | disclosed |
| EP-0225886-B1 | NEW PYRIDAZINE COMPOSITIONS, PRODUCTION PROCESS THEREOF AND FUNGICIDES AND ALGICIDES CONTAINING THEM | AGROLINZ AGRARCHEMIKALIEN GESELLSCHAFT M.B.H. (AT) | 1990-06-20 | — | — | EP | disclosed |
| EP-0225886-A1 | NEW PYRIDAZINE COMPOSITIONS, PRODUCTION PROCESS THEREOF AND FUNGICIDES AND ALGICIDES CONTAINING THEM. | CHEMIE LINZ AG (AT) | 1987-06-24 | — | — | EP | disclosed |
| EP-0225886-A1 | NEW PYRIDAZINE COMPOSITIONS, PRODUCTION PROCESS THEREOF AND FUNGICIDES AND ALGICIDES CONTAINING THEM. | CHEMIE LINZ AG (AT) | 1987-06-24 | — | — | EP | disclosed |
| WO-1986006719-A1 | NEW PYRIDAZINE COMPOSITIONS, PRODUCTION PROCESS THEREOF AND FUNGICIDES AND ALGICIDES CONTAINING THEM | CHEMIE LINZ AKTIENGESELLSCHAFT (AT) | 1986-11-20 | — | — | WO | disclosed |
| WO-1986006719-A1 | NEW PYRIDAZINE COMPOSITIONS, PRODUCTION PROCESS THEREOF AND FUNGICIDES AND ALGICIDES CONTAINING THEM | CHEMIE LINZ AKTIENGESELLSCHAFT (AT) | 1986-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066430-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AURKC, AURKA, AURKB | NPC1 1051/4885RAB9A 1770/4885USP2 3071/4885 |
| US-11535597-B2 | Photoreactive ligands and uses thereof | CLTB, CRYAB, CRYAA | NPC1 4135/4885RAB9A 634/4885USP2 1446/4885 |
| US-20070185111-A1 | Aurora kinase modulators and method of use | AURKC, AURKA, CDK1 | NPC1 996/4885RAB9A 2470/4885USP2 3035/4885 |
| US-20120245125-A1 | PYRIDAZINE COMPOUNDS, COMPOSITIONS AND METHODS | PSEN1, PSEN2, APP | NPC1 2193/4885RAB9A 4169/4885USP2 3051/4885 |
| US-20200071277-A1 | PHOTOREACTIVE LIGANDS AND USES THEREOF | CLTB, CRYAB, CRYAA | NPC1 4135/4885RAB9A 634/4885USP2 1446/4885 |
| US-20110263530-A1 | Aurora Kinase Modulators and Method of Use | AURKC, AURKA, AURKB | NPC1 1051/4885RAB9A 1770/4885USP2 3071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.