SCHEMBL24045947

SCHEMBL24045947

CSNCc1ccccc1-c1ccc(N2CCC=CC2=O)c(F)c1

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F10 P00742 15/20 0.35
KCNH2 Q12809 1/20 0.35
ALOX5AP P20292 2/20 0.33
FEN1 P39748 2/20 0.33
KCNA5 P22460 1/20 0.33
FPR1 P21462 1/20 0.32
FPR2 P25090 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24045713 0.83 F10 (0.35) F10FPR1FPR2
SCHEMBL24045869 0.81 ALOX5AP (0.42) F10ALOX5APFEN1FPR1FPR2
SCHEMBL24045881 0.80 PTPRC (0.42) F10ALOX5APFEN1
SCHEMBL24045792 0.79 CNR2 (0.35) F10
SCHEMBL24045888 0.78 F10 (0.36) F10FPR1FPR2
SCHEMBL24045789 0.76 FPR2 (0.52) F10ALOX5APFEN1FPR1FPR2
SCHEMBL24045787 0.75 FPR2 (0.35) F10ALOX5APFEN1FPR1FPR2
SCHEMBL24045712 0.74 FPR1 (0.49) ALOX5APFEN1FPR1FPR2
SCHEMBL24045887 0.73 CYP11B2 (0.40) F10ALOX5APFEN1
SCHEMBL24045882 0.68 ROCK2 (0.39) F10FPR1FPR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3414227-B1 PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS BRISTOL MYERS SQUIBB CO (US) 2021-11-24 EP disclosed