Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.56 |
| ▸ | PPARG | P37231 | 3/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30694898 | 0.75 | PPARG (0.69) | CYP11B1CYP11B2PPARGSIGMAR1RAB9A | |
| SCHEMBL3715533 | 0.75 | PPARG (0.69) | CYP11B1CYP11B2PPARGSIGMAR1RAB9A | |
| SCHEMBL3660694 | 0.73 | PPARG (0.65) | CYP11B1CYP11B2PPARGSIGMAR1PLA2G2A | |
| SCHEMBL24046842 | 0.72 | PPARG (0.78) | CYP11B1CYP11B2PPARGSIGMAR1PLA2G2A | |
| SCHEMBL19925815 | 0.72 | PPARG (0.69) | CYP11B1CYP11B2PPARGSIGMAR1RAB9A | |
| SCHEMBL292258 | 0.72 | PPARG (0.69) | CYP11B1CYP11B2PPARGSIGMAR1RAB9A | |
| SCHEMBL7297515 | 0.72 | CYP11B1 (1.00) | CYP11B1CYP11B2SIGMAR1CYP19A1 | |
| SCHEMBL9972758 | 0.72 | PPARG (0.63) | CYP11B1CYP11B2PPARGSIGMAR1RAB9A | |
| SCHEMBL30876965 | 0.72 | PPARG (0.63) | CYP11B1CYP11B2PPARGSIGMAR1RAB9A | |
| SCHEMBL3662892 | 0.72 | ALOX15 (0.68) | CYP11B1CYP11B2PPARGSIGMAR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021236578-A1 | CHROMEN-4-ONE DERIVATIVES, SUCH AS E.G. FLAVONES, FOR USE AS CK2 INHIBITORS FOR THE TREATMENT OF NEUROINFLAMMATION | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2021-11-25 | — | — | WO | disclosed |