Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1837909 | 0.88 | ALDH1A1 (0.55) | ALDH1A1LMNATSHRTDP1ESR1 | |
| SCHEMBL22959441 | 0.75 | NPC1 (0.47) | LMNATDP1SLC6A2MMP1MMP9 | |
| SCHEMBL17477620 | 0.71 | MCL1 (0.44) | ALDH1A1TSHRTDP1L3MBTL1KDM4E | |
| SCHEMBL20267839 | 0.71 | ALDH1A1 (0.42) | ALDH1A1LMNATSHRTDP1ESR1 | |
| SCHEMBL27543772 | 0.70 | ALDH1A1 (0.49) | ALDH1A1LMNATSHRTDP1ESR1 | |
| SCHEMBL6342524 | 0.70 | ALDH1A1 (0.41) | ALDH1A1LMNATSHRTDP1ESR1 | |
| SCHEMBL17477664 | 0.70 | TSHR (0.46) | ALDH1A1TSHRL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL22724094 | 0.70 | IDH1 (0.40) | ALDH1A1LMNATSHRTDP1L3MBTL1 | |
| SCHEMBL11990342 | 0.70 | IDH1 (0.40) | ALDH1A1TDP1MMP1MMP9MMP12 | |
| SCHEMBL1256567 | 0.69 | CA12 (0.47) | ALDH1A1TSHRTDP1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8795630-B2 | Butyrylcholinesterase ligands as diagnostic tools and treatment for diseases of the nervous system | TREVENTIS CORPORATION (US) | 2014-08-05 | — | — | US | disclosed |
| EP-2320891-B1 | BUTYRYLCHOLINESTERASE LIGANDS AS DIAGNOSTIC TOOLS AND TREATMENT FOR DESEASES OF THE NERVOUS SYSTEM | TREVENTIS CORP (US) | 2013-10-09 | — | — | EP | disclosed |
| US-20110212026-A1 | BUTYRYLCHOLINESTERASE LIGANDS AS DIAGNOSTIC TOOLS AND TREATMENT FOR DESEASES OF THE NERVOUS SYSTEM | TREVENTIS CORPORATION | 2011-09-01 | — | — | US | disclosed |
| CN-102164598-A | Butyrylcholinesterase ligands as diagnostic tools and therapeutics for neurological diseases | TREVENTIS CORP | 2011-08-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212026-A1 | BUTYRYLCHOLINESTERASE LIGANDS AS DIAGNOSTIC TOOLS AND TREATMENT FOR DESEASES OF THE NERVOUS SYSTEM | BCHE, ACHE, CERS2 | ALDH1A1 1760/4885LMNA 1775/4885TSHR 979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.