Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17477620 | 0.81 | MCL1 (0.44) | IDH1SLC18A3ALDH1A1CA12BRD4 | |
| SCHEMBL22724094 | 0.79 | IDH1 (0.40) | IDH1SLC18A3ALDH1A1CA12BRD4 | |
| SCHEMBL14441730 | 0.77 | ALDH1A1 (0.33) | ALDH1A1MCL1 | |
| SCHEMBL2789862 | 0.77 | IDH1 (0.60) | IDH1ALDH1A1MAPTHDAC4HDAC1 | |
| SCHEMBL2413275 | 0.76 | KDM4E (0.45) | IDH1ALDH1A1CA12BRD4CA9 | |
| SCHEMBL2404923 | 0.70 | ALDH1A1 (0.50) | ALDH1A1MMP1MMP9MMP12TDP1 | |
| SCHEMBL17471570 | 0.70 | S1PR4 (0.56) | ALDH1A1MEN1KMT2AMAPTHDAC4 | |
| SCHEMBL17296431 | 0.70 | ALDH1A1 (0.33) | ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL194181 | 0.70 | — | — | |
| SCHEMBL17477700 | 0.69 | PTGS2 (0.51) | ALDH1A1MEN1KMT2AMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556122-B2 | Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-01-31 | — | — | US | disclosed |
| US-20160320399-A1 | MACROCYCLIC HOPO CHELATORS | LUMIPHORE, INC. | 2016-11-03 | — | — | US | disclosed |
| US-9273059-B2 | Macrocyclic HOPO chelators | LUMIPHORE, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-20140039169-A1 | LUMINESCENT 1-HYDROXY-2-PYRIDINONE CHELATES OF LANTHANIDES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2014-02-06 | — | — | US | disclosed |
| US-20120214253-A1 | MACROCYCLIC HOPO CHELATORS | LUMIPHORE, INC. (US) | 2012-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140039169-A1 | LUMINESCENT 1-HYDROXY-2-PYRIDINONE CHELATES OF LANTHANIDES | PLPBP, HPD, LASP1 | IDH1 25/4885SLC18A3 1997/4885ALDH1A1 411/4885 |
| US-20160320399-A1 | MACROCYCLIC HOPO CHELATORS | PHPT1, SSB, CD69 | IDH1 256/4885SLC18A3 1195/4885ALDH1A1 4846/4885 |
| US-20120214253-A1 | MACROCYCLIC HOPO CHELATORS | PHPT1, SSB, CD69 | IDH1 256/4885SLC18A3 1195/4885ALDH1A1 4846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.