Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | MTNR1A | P48039 | 12/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 12/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24061162 | 0.85 | L3MBTL1 (0.61) | L3MBTL1MTNR1AMTNR1B | |
| SCHEMBL26378352 | 0.83 | L3MBTL1 (0.58) | L3MBTL1MTNR1AMTNR1B | |
| SCHEMBL17164070 | 0.81 | POLB (0.66) | L3MBTL1POLBDRD2DRD4HPGD | |
| SCHEMBL17164162 | 0.79 | L3MBTL1 (0.68) | L3MBTL1MTNR1AMTNR1BDRD2DRD4 | |
| SCHEMBL17164001 | 0.78 | L3MBTL1 (0.75) | L3MBTL1MTNR1AMTNR1B | |
| SCHEMBL29292080 | 0.78 | DRD2 (0.54) | L3MBTL1POLBDRD2DRD4HPGD | |
| SCHEMBL8265682 | 0.78 | ALDH1A1 (0.52) | L3MBTL1POLBDRD2DRD4DRD3 | |
| SCHEMBL8908445 | 0.77 | L3MBTL1 (0.53) | L3MBTL1MTNR1AMTNR1B | |
| SCHEMBL12958255 | 0.77 | DRD2 (0.48) | L3MBTL1DRD2DRD4DRD3 | |
| Dimethylamine SCHEMBL9870402 | 0.77 | POLB (0.60) | L3MBTL1POLBDRD2DRD4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157844-B1 | 4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER | CENTRE NAT RECH SCIENT (FR) | 2024-07-10 | — | — | EP | disclosed |
| WO-2021239727-A1 | 4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2021-12-02 | — | — | WO | disclosed |
| EP-3915990-A1 | 4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER | Centre National de la Recherche Scientifique (FR) | 2021-12-01 | — | — | EP | disclosed |