Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.59 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2435054 | 0.89 | NR1H4 (0.49) | SMN1; SMN2CYP26A1CYP26B1HSD17B10MITF | |
| SCHEMBL2406810 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2CYP26A1CYP26B1HSD17B10MEN1 | |
| SCHEMBL2406820 | 0.85 | NPC1 (0.53) | SMN1; SMN2CYP26A1CYP26B1HSD17B10MITF | |
| SCHEMBL2405602 | 0.84 | MAPT (0.52) | SMN1; SMN2CYP26A1CYP26B1KDM4EMEN1 | |
| SCHEMBL2405592 | 0.82 | SMN1; SMN2 (0.44) | SMN1; SMN2CYP26A1CYP26B1KDM4ETP53 | |
| SCHEMBL2407431 | 0.81 | THRB (0.55) | SMN1; SMN2HSD17B10MEN1TP53KMT2A | |
| SCHEMBL2405272 | 0.80 | KMT2A (0.43) | SMN1; SMN2CYP26A1CYP26B1KDM4EMEN1 | |
| SCHEMBL2411251 | 0.79 | RARA (0.46) | SMN1; SMN2CYP26A1CYP26B1HSD17B10MITF | |
| SCHEMBL2405520 | 0.79 | PKM (0.51) | SMN1; SMN2CYP26A1CYP26B1HSD17B10KDM4E | |
| SCHEMBL2410253 | 0.78 | MEN1 (0.47) | SMN1; SMN2CYP26A1CYP26B1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722730-B2 | 5-membered heterocyclic compound | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2014-05-13 | — | — | US | disclosed |
| US-8722730-B2 | 5-membered heterocyclic compound | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2014-05-13 | — | — | US | disclosed |
| US-20110213156-A1 | 5-MEMBERED HETEROCYCLIC COMPOUND | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2011-09-01 | — | — | US | disclosed |
| US-20110213156-A1 | 5-MEMBERED HETEROCYCLIC COMPOUND | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2011-09-01 | — | — | US | disclosed |
| EP-2189445-A1 | FIVE-MEMBERED HETEROCYCLIC COMPOUND | Research Foundation Itsuu Laboratory (JP) | 2010-05-26 | — | — | EP | disclosed |
| EP-2189445-A1 | FIVE-MEMBERED HETEROCYCLIC COMPOUND | Research Foundation Itsuu Laboratory (JP) | 2010-05-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110213156-A1 | 5-MEMBERED HETEROCYCLIC COMPOUND | RXRA, RXRG, RXRB | SMN1; SMN2 2833/4885CYP26A1 231/4885CYP26B1 174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.