Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pyrilamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 0.80 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.80 |
| ▸ | DRD1 | P21728 | 3/20 | 0.80 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.80 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.80 |
| ▸ | HTR2A | P28223 | 2/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.80 |
| ▸ | TSHR | P16473 | 2/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.80 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrilamine SCHEMBL97901 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL27430 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL27517034 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL97902 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL5907722 | 0.99 | SMN1; SMN2 (0.98) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL11313804 | 0.92 | SMN1; SMN2 (0.84) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL9666725 | 0.91 | SMN1; SMN2 (0.82) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL9666718 | 0.91 | SMN1; SMN2 (0.82) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL4945522 | 0.90 | SMN1; SMN2 (0.81) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL622845 | 0.90 | LMNA (0.95) | SMN1; SMN2BLMPMP22HRH1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212090-A1 | Combinatorial Analysis and Repair | DAKO DENMARK A/S | 2011-09-01 | — | — | US | disclosed |