Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pyrilamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 0.80 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.80 |
| ▸ | DRD1 | P21728 | 3/20 | 0.80 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.80 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.80 |
| ▸ | HTR2A | P28223 | 2/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.80 |
| ▸ | TSHR | P16473 | 2/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.80 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrilamine SCHEMBL2406435 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL27430 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL27517034 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL97902 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL5907722 | 0.99 | SMN1; SMN2 (0.98) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL11313804 | 0.92 | SMN1; SMN2 (0.84) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL9666725 | 0.91 | SMN1; SMN2 (0.82) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL9666718 | 0.91 | SMN1; SMN2 (0.82) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL4945522 | 0.90 | SMN1; SMN2 (0.81) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL622845 | 0.90 | LMNA (0.95) | SMN1; SMN2BLMPMP22HRH1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3298 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260117393-A1 | ETCHING AGENT COMPOSITION AND ETCHING METHOD USING THE SAME | KCTECH CO., LTD. (KR) | 2026-04-30 | — | — | US | claimed |
| US-20250262177-A1 | METHOD TO ALLEVIATE THE SYMPTOMS OF PMS | CASH ALAN B (US) | 2025-08-21 | — | — | US | claimed |
| EP-4581071-A1 | METHOD FOR PRODUCING A MATERIAL FOR A MEMBRANE, MATERIAL, MEMBRANE AND USE OF A MEMBRANE | Forschungszentrum Jülich GmbH (DE) | 2025-07-09 | — | — | EP | claimed |
| CN-120048406-A | Self-compacting concrete construction quality control method, device and equipment based on machine learning | 中电建生态环境集团有限公司 | 2025-05-27 | — | — | CN | claimed |
| CN-119773295-A | Anti-hanging punching device of tablet press | 山西太原药业有限公司 | 2025-04-08 | — | — | CN | claimed |
| CN-119080687-A | Pyridyl perovskite nanocrystalline material and preparation and application thereof | 同济大学 | 2024-12-06 | — | — | CN | claimed |
| CN-221607602-U | Small-size hoist device in restricted space | 南通振华重型装备制造有限公司 | 2024-08-27 | — | — | CN | claimed |
| US-20240189227-A1 | EASY CHEW FORMULATIONS | HALEON US HOLDINGS LLC | 2024-06-13 | — | — | US | claimed |
| CN-117864969-A | Anti-hanging monitoring method, engineering machinery and computing equipment | 三一海洋重工有限公司 | 2024-04-12 | — | — | CN | claimed |
| CN-117874560-A | Method, device, equipment and medium for realizing user fine layering | 武汉国信映盛互动技术有限公司 | 2024-04-12 | — | — | CN | claimed |
| US-4762704-A | Antiperspirant compositions, containing certain antihistamines and certain antihistamine enhancers | BRISTOL-MYERS COMPANY (US) | 1988-08-09 | — | — | US | claimed |
| US-4753800-A | DRUGS ADSORBED ONTO MAGNESIUM ALUMINUM STEARATE | WARNER-LAMBERT COMPANY (US) | 1988-06-28 | — | — | US | claimed |
| EP-0219458-A2 | Medicament adsorbates and their preparation | WARNER-LAMBERT COMPANY (US) | 1987-04-22 | — | — | EP | claimed |
| US-4654209-A | NITROGLYCERINE PLUS STEROID, ANTIHISTAMINE, ANALGESIC, ANTIMICROBIAL | EUROCELTIQUE, S.A. (LU) | 1987-03-31 | — | — | US | claimed |
| US-4642231-A | Magnesium trisilicate suitable for preparation of medicament adsorbates of antihistamines | WARNER-LAMBERT COMPANY (US) | 1987-02-10 | — | — | US | claimed |
| EP-0132472-A1 | Medicated products containing a magnesium trisilicate adsorbent with a medicament drug adsorbed thereon | WARNER-LAMBERT COMPANY (US) | 1985-02-13 | — | — | EP | claimed |
| US-4466960-A | Analgesic-diuretic compositions | THOMPSON MEDICAL CO., INC. (US) | 1984-08-21 | — | — | US | claimed |
| EP-0081823-A1 | Composition for reducing menstrual pain | WHITBY RESEARCH, Inc. (US) | 1983-06-22 | — | — | EP | claimed |
| US-4269835-A | Nasal composition for relieving nasal distress | WHITTLE BARRY J | 1981-05-26 | — | — | US | claimed |
| US-4256743-A | PHENOTHIAZINES, ETHYLENEDIAMINES, INDENES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1981-03-17 | — | — | US | claimed |