Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pyrilamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 0.80 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.80 |
| ▸ | DRD1 | P21728 | 3/20 | 0.80 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.80 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.80 |
| ▸ | HTR2A | P28223 | 2/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.80 |
| ▸ | TSHR | P16473 | 2/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.80 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrilamine SCHEMBL2406435 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL97901 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL27517034 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL97902 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL5907722 | 0.99 | SMN1; SMN2 (0.98) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL11313804 | 0.92 | SMN1; SMN2 (0.84) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL9666725 | 0.91 | SMN1; SMN2 (0.82) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL9666718 | 0.91 | SMN1; SMN2 (0.82) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL4945522 | 0.90 | SMN1; SMN2 (0.81) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL622845 | 0.90 | LMNA (0.95) | SMN1; SMN2BLMPMP22HRH1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 31065 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250262177-A1 | METHOD TO ALLEVIATE THE SYMPTOMS OF PMS | CASH ALAN B (US) | 2025-08-21 | — | — | US | claimed |
| EP-4149317-B1 | CASE | HOLOS PHARM SAGL (CH) | 2024-07-17 | — | — | EP | claimed |
| EP-3152034-B1 | MATERIAL PROCESSING METHODS AND RELATED APPARATUS | HYBRID MANUFACTURING TECH LIMITED (GB) | 2024-07-17 | — | — | EP | claimed |
| EP-3739138-B1 | A PLAYGROUND | KOMPAN AS (DK) | 2024-07-10 | — | — | EP | claimed |
| EP-3503814-B1 | INSTRUMENTATION FOR THE IMPLANTATION OF SPINAL IMPLANTS | STRYKER EUROPEAN OPERATIONS HOLDINGS LLC (US) | 2024-07-10 | — | — | EP | claimed |
| EP-3802215-B1 | VEHICLE FOR TRANSPORTING GOODS | FAYMONVILLE DISTRIB AG (LU) | 2024-07-03 | — | — | EP | claimed |
| EP-4222373-B1 | HOIST ARRANGEMENT FOR A WIND TURBINE BLADE ACCESS PLATFORM | PP ENERGY APS (DK) | 2024-07-03 | — | — | EP | claimed |
| EP-4393851-A1 | LONG-LENGTH WOOD SORTING DEVICE | Hans Hundegger Beteiligungs GmbH & Co. KG (DE) | 2024-07-03 | — | — | EP | claimed |
| EP-4390117-A1 | LIFTING MEANS FOR LIFTING A COMPONENT OF A WIND TURBINE | Wobben Properties GmbH (DE) | 2024-06-26 | — | — | EP | claimed |
| EP-4388925-A1 | FIRST AID CASE, EMERGENCY CASE AND EMERGENCY CASE HALF, METHOD FOR CONNECTING TWO EMERGENCY CASE HALVES AND USE OF AN EMERGENCY CASE HALF | W. Söhngen GmbH (DE) | 2024-06-26 | — | — | EP | claimed |
| EP-0004858-A2 | Bending apparatus for tubes | L. ID. IT dei F.lli Belotti (IT) | 1979-10-31 | — | — | EP | claimed |
| EP-0004282-A2 | Hospital bed | Joh. Stiegelmeyer & Co. GmbH (DE) | 1979-10-03 | — | — | EP | claimed |
| WO-1979000682-A1 | MACHINE FOR UNTYING AND REMOVING THE STRINGS AND BINDERS OF PACKED GOODS | BORN AG P (CH) | 1979-09-20 | — | — | WO | claimed |
| EP-0003998-A2 | Machine for working a web of material by a welding tool | STIEGLER GMBH MASCHINENFABRIK (DE) | 1979-09-19 | — | — | EP | claimed |
| WO-1979000666-A1 | MEASURING DEVICE FOR CHILLS IN CHILL-MOULDS FOR METAL,PARTICULARLY FOR STEEL | SSAB SVENSKT STAL AB (SE) | 1979-09-06 | — | — | WO | claimed |
| EP-0003574-A1 | Method for positioning and supplying a stock of cups or closures, or longish tubular or bottle-like containers or the like to a filling machine | Wiener Innovationsgesellschaft m.b.H. (AT) | 1979-08-22 | — | — | EP | claimed |
| EP-0002188-A1 | Treadmill for the therapy and rehabilitation of persons hampered in walking | Schönenberger, Willi (CH) | 1979-06-13 | — | — | EP | claimed |
| EP-0001967-A1 | Apparatus for packing groups of articles in containers | FOCKE & CO. (DE) | 1979-05-30 | — | — | EP | claimed |
| EP-0001032-A1 | Gas laser with transversal excitation | ELTRO GmbH Gesellschaft für Strahlungstechnik (DE) | 1979-03-07 | — | — | EP | claimed |
| EP-0000065-A1 | Process and apparatus for bundling rods, tubes, profiles, and other oblong objects | kabelmetal Messingwerke GmbH (DE) | 1978-12-20 | — | — | EP | claimed |