Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pyrilamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 0.80 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.80 |
| ▸ | DRD1 | P21728 | 3/20 | 0.80 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.80 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.80 |
| ▸ | HTR2A | P28223 | 2/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.80 |
| ▸ | TSHR | P16473 | 2/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.80 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrilamine SCHEMBL2406435 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL97901 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL27430 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL27517034 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL5907722 | 0.99 | SMN1; SMN2 (0.98) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL11313804 | 0.92 | SMN1; SMN2 (0.84) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL9666725 | 0.91 | SMN1; SMN2 (0.82) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL9666718 | 0.91 | SMN1; SMN2 (0.82) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL4945522 | 0.90 | SMN1; SMN2 (0.81) | SMN1; SMN2BLMPMP22HRH1LMNA | |
| Pyrilamine SCHEMBL622845 | 0.90 | LMNA (0.95) | SMN1; SMN2BLMPMP22HRH1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2814 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250262177-A1 | METHOD TO ALLEVIATE THE SYMPTOMS OF PMS | CASH ALAN B (US) | 2025-08-21 | — | — | US | claimed |
| US-20240189227-A1 | EASY CHEW FORMULATIONS | HALEON US HOLDINGS LLC | 2024-06-13 | — | — | US | claimed |
| US-20240115529-A1 | METHOD TO ALLEVIATE THE SYMPTOMS OF PMS | CASH ALAN B (US) | 2024-04-11 | — | — | US | claimed |
| EP-4333895-A1 | EASY CHEW FORMULATIONS | Haleon US IP LLC (US) | 2024-03-13 | — | — | EP | claimed |
| EP-4327797-A2 | MULTI PHASE SOFT GEL CAPSULES, APPARATUS AND METHOD THEREOF | Catalent Ontario Limited (CA) | 2024-02-28 | — | — | EP | claimed |
| US-20240041777-A1 | PHARMACEUTICAL CAPSULE CONTAINING AT LEAST TWO TABLETS | RB HEALTH US LLC (US) | 2024-02-08 | — | — | US | claimed |
| US-11865092-B2 | Method to alleviate the symptoms of PMS | CASH, ALAN B. | 2024-01-09 | — | — | US | claimed |
| EP-3319596-B1 | PHARMACEUTICAL COMPOSITIONS | UNIWELL LABORATORIES LLC (US) | 2023-12-20 | — | — | EP | claimed |
| EP-3515428-B1 | METHOD TO ALLEVIATE THE SYMPTOMS OF PMS | CASH ALAN B (US) | 2023-06-07 | — | — | EP | claimed |
| US-20230003721-A1 | MITOTHERAPEUTICS FOR THE TREATMENT OF BRAIN DISORDERS | THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2023-01-05 | — | — | US | claimed |
| US-4762704-A | Antiperspirant compositions, containing certain antihistamines and certain antihistamine enhancers | BRISTOL-MYERS COMPANY (US) | 1988-08-09 | — | — | US | claimed |
| US-4753800-A | DRUGS ADSORBED ONTO MAGNESIUM ALUMINUM STEARATE | WARNER-LAMBERT COMPANY (US) | 1988-06-28 | — | — | US | claimed |
| EP-0219458-A2 | Medicament adsorbates and their preparation | WARNER-LAMBERT COMPANY (US) | 1987-04-22 | — | — | EP | claimed |
| US-4654209-A | NITROGLYCERINE PLUS STEROID, ANTIHISTAMINE, ANALGESIC, ANTIMICROBIAL | EUROCELTIQUE, S.A. (LU) | 1987-03-31 | — | — | US | claimed |
| US-4642231-A | Magnesium trisilicate suitable for preparation of medicament adsorbates of antihistamines | WARNER-LAMBERT COMPANY (US) | 1987-02-10 | — | — | US | claimed |
| EP-0132472-A1 | Medicated products containing a magnesium trisilicate adsorbent with a medicament drug adsorbed thereon | WARNER-LAMBERT COMPANY (US) | 1985-02-13 | — | — | EP | claimed |
| US-4466960-A | Analgesic-diuretic compositions | THOMPSON MEDICAL CO., INC. (US) | 1984-08-21 | — | — | US | claimed |
| EP-0081823-A1 | Composition for reducing menstrual pain | WHITBY RESEARCH, Inc. (US) | 1983-06-22 | — | — | EP | claimed |
| US-4269835-A | Nasal composition for relieving nasal distress | WHITTLE BARRY J | 1981-05-26 | — | — | US | claimed |
| US-4256743-A | PHENOTHIAZINES, ETHYLENEDIAMINES, INDENES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1981-03-17 | — | — | US | claimed |