SCHEMBL2406458

SCHEMBL2406458

NS(=O)(=O)c1ccc(-c2cccc(N3CCC(CCN(Cc4cscn4)C(=O)O)CC3)n2)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CKS1B P61024 1/20 0.35
SKP1 P63208 1/20 0.35
SKP2 Q13309 1/20 0.35
CA12 O43570 5/20 0.34
CA1 P00915 5/20 0.34
CA2 P00918 5/20 0.34
CA7 P43166 5/20 0.34
CA9 Q16790 4/20 0.34
CA14 Q9ULX7 1/20 0.34
FFAR4 Q5NUL3 4/20 0.33
CA4 P22748 3/20 0.33
PHGDH O43175 1/20 0.33
TNF P01375 1/20 0.33
LMNA P02545 1/20 0.33
STAT3 P40763 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
NOD2 Q9HC29 1/20 0.33
NOD1 Q9Y239 1/20 0.33
SMO Q99835 1/20 0.33
CASR P41180 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2408573 0.90 ALDH1A1 (0.39) FFAR4PHGDHTNFLMNASTAT3
SCHEMBL2407695 0.89 CPT2 (0.34) CKS1BSKP1SKP2FFAR4TGFBR1
SCHEMBL2407363 0.89 CNR1 (0.37) FFAR4AGTR2
SCHEMBL2407375 0.89 CKS1B (0.40) CKS1BSKP1SKP2FFAR4SMN1; SMN2
SCHEMBL2406554 0.87 JAK2 (0.38) CKS1BSKP1SKP2FFAR4SMO
SCHEMBL2406949 0.86 CNR1 (0.39) FFAR4LMNASMN1; SMN2
SCHEMBL2406117 0.86 HSD11B1 (0.37) CKS1BSKP1SKP2FFAR4AGTR2
SCHEMBL2407041 0.86 NPC1 (0.42) CKS1BSKP1SKP2FFAR4
SCHEMBL2408149 0.86 FFAR1 (0.37) FFAR4
SCHEMBL2411223 0.86 FFAR4 (0.36) CKS1BSKP1SKP2FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8912218-B2 Alkylthiazol carbamate derivatives, preparation thereof and therapeutic use thereof SANOFI (FR) 2014-12-16 US disclosed
US-20110212963-A1 ALKYLTHIAZOL CARBAMATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2011-09-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110212963-A1 ALKYLTHIAZOL CARBAMATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF MET, ALK, REL CKS1B 2188/4885SKP1 3476/4885SKP2 3826/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.