SCHEMBL2408149

SCHEMBL2408149

O=C(O)N(CCC1CCN(c2cccc(-c3ccc(OCC4CC4)cc3)n2)CC1)Cc1cscn1

nearest known ligand 0.37

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.37
FFAR4 Q5NUL3 7/20 0.35
CXCR1 P25024 1/20 0.35
GPR119 Q8TDV5 1/20 0.35
TTR P02766 1/20 0.34
DGAT1 O75907 5/20 0.33
CTSA P10619 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2406949 0.91 CNR1 (0.39) FFAR4
SCHEMBL2407375 0.89 CKS1B (0.40) FFAR4TTR
SCHEMBL2407363 0.89 CNR1 (0.37) FFAR4DGAT1
SCHEMBL2407342 0.87 DKK1 (0.41) FFAR4DGAT1
SCHEMBL2407695 0.87 CPT2 (0.34) FFAR4DGAT1
SCHEMBL2406117 0.86 HSD11B1 (0.37) FFAR1FFAR4
SCHEMBL2411223 0.86 FFAR4 (0.36) FFAR4DGAT1
SCHEMBL2406458 0.86 CKS1B (0.35) FFAR4
SCHEMBL2406862 0.85 CPT1A (0.37) FFAR4
SCHEMBL2405723 0.84 FFAR4 (0.41) FFAR1FFAR4CTSA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8912218-B2 Alkylthiazol carbamate derivatives, preparation thereof and therapeutic use thereof SANOFI (FR) 2014-12-16 US disclosed
US-20110212963-A1 ALKYLTHIAZOL CARBAMATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2011-09-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110212963-A1 ALKYLTHIAZOL CARBAMATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF MET, ALK, REL FFAR1 391/4885FFAR4 677/4885CXCR1 501/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.