Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18910392 | 0.97 | ALDH1A1 (0.41) | ALDH1A1HRH3HTTNPSR1ADRB2 | |
| SCHEMBL23512913 | 0.87 | HRH3 (0.38) | HRH3CYP19A1LMNARAB9A | |
| SCHEMBL26315521 | 0.85 | HRH3 (0.53) | ALDH1A1HRH3HTTNPSR1CYP19A1 | |
| SCHEMBL22071369 | 0.84 | KDM4E (0.41) | HRH3CYP19A1MAPTTRPV1NPC1 | |
| SCHEMBL24634304 | 0.82 | HRH3 (0.37) | HRH3CYP19A1LMNAMAPTNPC1 | |
| SCHEMBL26315400 | 0.80 | HRH3 (0.38) | HRH3CYP19A1LMNAMAPTNPC1 | |
| SCHEMBL22663605 | 0.80 | RAB9A (0.46) | ALDH1A1NPSR1LMNAMAPTNPC1 | |
| SCHEMBL9869995 | 0.79 | HRH3 (0.42) | HRH3HTTCYP19A1LMNAMAPT | |
| SCHEMBL30567467 | 0.78 | ALDH1A1 (0.52) | ALDH1A1HTTNPSR1LMNAHSP90AA1 | |
| SCHEMBL85405 | 0.78 | ALDH1A1 (0.52) | ALDH1A1HTTNPSR1LMNAHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210371375-A1 | hTERT MODULATORS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210371375-A1 | hTERT MODULATORS AND METHODS OF USE | TERT, TERF2, RB1 | ALDH1A1 2287/4885HRH3 1225/4885HTT 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.