Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.38 |
| ▸ | ORAI2 | Q96SN7 | 2/20 | 0.38 |
| ▸ | ORAI3 | Q9BRQ5 | 2/20 | 0.38 |
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 5/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12270774 | 0.83 | ORAI1 (0.40) | ORAI1ORAI2ORAI3TRPV6MAPT | |
| SCHEMBL2413097 | 0.80 | CYP3A4 (0.46) | ORAI1ORAI2ORAI3TRPV6MAPT | |
| SCHEMBL2404895 | 0.80 | ORAI1 (0.41) | ORAI1ORAI2ORAI3TRPV6CA1 | |
| SCHEMBL1349122 | 0.74 | CYP3A4 (0.48) | MAPTKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL257894 | 0.73 | CA2 (0.52) | CA1CA2HTR2ASLC6A4KCNH2 | |
| SCHEMBL2407444 | 0.73 | ORAI1 (0.47) | ORAI1ORAI2ORAI3HTR2ASLC6A4 | |
| SCHEMBL16693409 | 0.71 | CYP3A4 (0.45) | MAPTKDM4EALDH1A1KMT2ACYP3A4 | |
| SCHEMBL675954 | 0.70 | HTR2A (0.54) | HTR2ASLC6A4KCNH2MAPTKDM4E | |
| SCHEMBL13167946 | 0.69 | ENPP2 (0.73) | ORAI1ORAI2ORAI3TRPV6CA1 | |
| SCHEMBL6436949 | 0.67 | HTR2A (0.53) | HTR2ASLC6A4KCNH2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853424-B2 | Protein cross-linking inhibitor | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20110212919-A1 | PROTEIN CROSS-LINKING INHIBITOR | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212919-A1 | PROTEIN CROSS-LINKING INHIBITOR | BAZ2B, PRMT1, BRIX1 | ORAI1 4605/4885ORAI2 3906/4885ORAI3 4036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.