Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | PKM | P14618 | 7/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2406927 | 0.77 | PKM (0.47) | HDAC6HDAC8KMT2AMEN1PKM | |
| SCHEMBL2410992 | 0.76 | HDAC6 (0.59) | HDAC6HDAC8HDAC2KMT2AMEN1 | |
| SCHEMBL2411710 | 0.74 | PRMT1 (0.68) | HDAC6HDAC8HDAC2KMT2AMEN1 | |
| SCHEMBL20314701 | 0.73 | MEN1 (0.59) | KMT2AMEN1PKMCA12CA2 | |
| SCHEMBL2413993 | 0.72 | HDAC6 (0.58) | HDAC6HDAC8HDAC2KMT2AMEN1 | |
| SCHEMBL30626125 | 0.71 | AKR1C3 (0.58) | HDAC6HDAC8HDAC2KMT2AMEN1 | |
| SCHEMBL4923521 | 0.70 | POLB (0.72) | HDAC6HDAC8HDAC2KMT2AMEN1 | |
| SCHEMBL28781641 | 0.69 | PKM (0.56) | KMT2AMEN1PKMCA12KDM4E | |
| SCHEMBL2408423 | 0.68 | HDAC8 (0.47) | HDAC6HDAC8HDAC2KMT2AMEN1 | |
| SCHEMBL12707728 | 0.67 | KMT2A (0.80) | KMT2AMEN1CA12KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011106632-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-09-01 | — | — | WO | disclosed |