Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2411710 | 0.77 | PRMT1 (0.68) | HDAC8HDAC6HDAC2HDAC3ALDH1A1 | |
| SCHEMBL2408420 | 0.77 | NPC1 (0.45) | HDAC8HDAC6HDAC2KDM4ENPC1 | |
| SCHEMBL2413993 | 0.75 | HDAC6 (0.58) | HDAC8HDAC6HDAC2HDAC3ALDH1A1 | |
| SCHEMBL12077931 | 0.74 | NAMPT (0.71) | KDM4ENPC1PKMALDH1A1KMT2A | |
| SCHEMBL14058132 | 0.71 | LMNA (0.59) | PKMALDH1A1KMT2ALMNAPOLB | |
| SCHEMBL2410992 | 0.71 | HDAC6 (0.59) | HDAC8HDAC6HDAC2HDAC3KMT2A | |
| SCHEMBL2407414 | 0.68 | NPC1 (0.50) | HDAC8HDAC6HDAC2KDM4ENPC1 | |
| SCHEMBL11305429 | 0.68 | KMT2A (0.61) | KDM4ENPC1PKMALDH1A1KMT2A | |
| SCHEMBL14969344 | 0.68 | KMT2A (0.61) | PKMKMT2ALMNAPOLBMEN1 | |
| SCHEMBL2407780 | 0.68 | HDAC6 (0.52) | HDAC8HDAC6HDAC2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011106632-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-09-01 | — | — | WO | disclosed |