Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 2/20 | 0.65 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.65 |
| ▸ | GRM5 | P41594 | 6/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12320837 | 0.87 | KCNK3 (0.61) | KCNK3KCNK9GRM5HSD11B1POLB | |
| SCHEMBL12320839 | 0.85 | KCNK3 (0.57) | KCNK3KCNK9GRM5CDK4CCND1 | |
| SCHEMBL2407592 | 0.83 | KCNK3 (0.55) | KCNK3KCNK9GRM5HSD11B1CDK4 | |
| SCHEMBL2407040 | 0.82 | KCNK3 (0.87) | KCNK3KCNK9HSD11B1POLBHTR2B | |
| SCHEMBL30664070 | 0.79 | KCNK3 (1.00) | KCNK3KCNK9POLBHTR2B | |
| SCHEMBL2406138 | 0.79 | KCNK3 (1.00) | KCNK3KCNK9POLBHTR2B | |
| SCHEMBL2410232 | 0.78 | KCNK3 (0.72) | KCNK3KCNK9CDK4CCND1SLC6A7 | |
| SCHEMBL2410478 | 0.77 | KCNK3 (0.73) | KCNK3KCNK9SLC6A7POLBHTR2B | |
| SCHEMBL2407042 | 0.75 | KCNK3 (0.68) | KCNK3KCNK9SLC6A7POLBHTR2B | |
| SCHEMBL2406140 | 0.74 | KCNK3 (0.66) | KCNK3KCNK9SLC6A7NAMPTHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011103715-A1 | TASK CHANNEL ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2011-09-01 | — | — | WO | claimed |
| WO-2011106276-A1 | TASK CHANNEL ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2011-09-01 | — | — | WO | claimed |
| WO-2011103715-A1 | TASK CHANNEL ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2011-09-01 | — | — | WO | disclosed |
| WO-2011103715-A1 | TASK CHANNEL ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2011-09-01 | — | — | WO | disclosed |