SCHEMBL240811

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL12012112	0.94	TDP1 (0.46)	TDP1TSHRMAPK1ALDH1A1CYP3A4
	SCHEMBL36226	0.91	TSHR (0.40)	TDP1TSHRMAPK1ALDH1A1LTA4H
	SCHEMBL21089712	0.86	LTA4H (0.40)	TSHRMAPK1ALDH1A1LTA4H
	SCHEMBL36335	0.86	TSHR (0.37)	TSHRMAPK1ALDH1A1CYP3A4RAB9A
	SCHEMBL1127852	0.85	TSHR (0.39)	TSHRALDH1A1CYP3A4GAAL3MBTL1
	SCHEMBL13337534	0.84	FKBP1A (0.42)	TSHRMAPK1ALDH1A1RAB9AL3MBTL1
	SCHEMBL15334058	0.83	LTA4H (0.38)	TSHRSMN1; SMN2L3MBTL1LTA4H
	SCHEMBL21074919	0.83	APP (0.41)	TSHRAPP
	SCHEMBL10071618	0.83	TSHR (0.37)	TDP1TSHRALDH1A1APPMAOB
	SCHEMBL12227651	0.83	FKBP1A (0.41)	TDP1TSHRALDH1A1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.