Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 6/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1830977 | 0.89 | SSTR4 (0.38) | SOS1CACNA1GCACNA1BCACNA1CSSTR4 | |
| SCHEMBL2409140 | 0.87 | POLB (0.36) | SOS1CACNA1GCACNA1BCACNA1CSSTR4 | |
| SCHEMBL4416056 | 0.86 | TACR1 (0.36) | SSTR4TACR1RIPK1NTRK1 | |
| SCHEMBL2410739 | 0.84 | PLCG1 (0.37) | SOS1CACNA1GCACNA1BCACNA1CSSTR4 | |
| SCHEMBL2408759 | 0.80 | DHODH (0.33) | SSTR4TACR1SLC6A4NTRK1 | |
| SCHEMBL2407583 | 0.76 | SOS1 (0.36) | SOS1SSTR4PDK2TACR1HTR2C | |
| SCHEMBL2408643 | 0.74 | SOS1 (0.33) | SOS1SSTR4PDK2TACR1HTR2C | |
| SCHEMBL2194154 | 0.73 | NAPRT (0.38) | TACR1RIPK1 | |
| SCHEMBL2409767 | 0.73 | HTR2C (0.38) | CACNA1GCACNA1BCACNA1CSSTR4PDK2 | |
| SCHEMBL30439835 | 0.73 | IDO1 (0.42) | SOS1CACNA1GCACNA1BCACNA1CPDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364979-A1 | Pyrrole compounds | Takeda Pharmaceutical Company Limited (JP) | 2011-09-14 | — | — | EP | disclosed |
| EP-2114917-A2 | PYRROLE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008108380-A2 | PYRROLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-12 | — | — | WO | disclosed |