Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1830980 | 0.89 | NAPRT (0.33) | DHODHNTRK1FFAR4 | |
| SCHEMBL2416412 | 0.87 | DHODH (0.32) | DHODHNTRK1FFAR4 | |
| SCHEMBL4416056 | 0.86 | TACR1 (0.36) | DHODHNTRK1SSTR4FFAR4TACR1 | |
| SCHEMBL2410567 | 0.84 | PLCG1 (0.35) | — | |
| SCHEMBL2408757 | 0.80 | SOS1 (0.41) | NTRK1SLC6A4SSTR4TACR1 | |
| SCHEMBL2407587 | 0.75 | DHODH (0.34) | DHODH | |
| SCHEMBL2408755 | 0.75 | WDR5 (0.33) | DHODHSSTR4 | |
| SCHEMBL4416060 | 0.74 | MTNR1A (0.42) | DHODH | |
| SCHEMBL2194154 | 0.73 | NAPRT (0.38) | DHODHFFAR4TACR1 | |
| SCHEMBL2408646 | 0.73 | RORC (0.33) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364979-A1 | Pyrrole compounds | Takeda Pharmaceutical Company Limited (JP) | 2011-09-14 | — | — | EP | disclosed |
| EP-2114917-A2 | PYRROLE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008108380-A2 | PYRROLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-12 | — | — | WO | disclosed |