Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 6/20 | 0.34 |
| ▸ | HTR2C | P28335 | 4/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2408643 | 0.93 | SOS1 (0.33) | SOS1HTR6HTR2CSLC6A4PDK2 | |
| SCHEMBL4999141 | 0.90 | HTR6 (0.37) | HTR6DHODHTNFSF11TACR1PTGDR2 | |
| SCHEMBL2412417 | 0.89 | HTR2C (0.35) | HTR6HTR2CSLC6A4F2TNFSF11 | |
| SCHEMBL2409996 | 0.87 | HTR6 (0.33) | HTR6HTR2CSLC6A4PDK2F2 | |
| SCHEMBL2409441 | 0.85 | HTR2C (0.35) | HTR6HTR2CSLC6A4PDK2F2 | |
| SCHEMBL2411042 | 0.84 | HTR6 (0.33) | HTR6HTR2CSLC6A4F2SSTR4 | |
| SCHEMBL4420269 | 0.83 | HTR6 (0.37) | HTR6HTR2CSLC6A4F2HTR2A | |
| SCHEMBL2411207 | 0.83 | HTR6 (0.39) | HTR6HTR2CSLC6A4 | |
| SCHEMBL2407587 | 0.83 | DHODH (0.34) | HTR6DHODHPTGDR2 | |
| SCHEMBL5005875 | 0.83 | HTR6 (0.35) | HTR6DHODHTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364979-A1 | Pyrrole compounds | Takeda Pharmaceutical Company Limited (JP) | 2011-09-14 | — | — | EP | disclosed |
| EP-2114917-A2 | PYRROLE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008108380-A2 | PYRROLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-12 | — | — | WO | disclosed |