Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | POLQ | O75417 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2407583 | 0.93 | SOS1 (0.36) | SOS1HTR6SSTR4TACR1HTR2C | |
| SCHEMBL2411042 | 0.92 | HTR6 (0.33) | GPBAR1PTK2RORCHTR6SSTR4 | |
| SCHEMBL2410573 | 0.90 | GPBAR1 (0.34) | GPBAR1HTR6HTR2CSLC6A4HTR2A | |
| SCHEMBL5005875 | 0.89 | HTR6 (0.35) | GPBAR1RORCHTR6TACR1POLQ | |
| SCHEMBL2408006 | 0.88 | PLCG1 (0.32) | HTR6KAT8 | |
| SCHEMBL2408646 | 0.83 | RORC (0.33) | GPBAR1RORCHTR6 | |
| SCHEMBL1832149 | 0.83 | HTR2C (0.33) | GPBAR1RORCHTR2CSLC6A4PDK2 | |
| SCHEMBL1833792 | 0.83 | KAT6A (0.32) | SSTR4HTR2CSLC6A4HTR2AF2 | |
| SCHEMBL1832665 | 0.82 | RORC (0.35) | GPBAR1RORCHTR2CSLC6A4PDK2 | |
| SCHEMBL4999141 | 0.82 | HTR6 (0.37) | HTR6TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364979-A1 | Pyrrole compounds | Takeda Pharmaceutical Company Limited (JP) | 2011-09-14 | — | — | EP | disclosed |
| EP-2114917-A2 | PYRROLE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008108380-A2 | PYRROLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-12 | — | — | WO | disclosed |