Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 3/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.30 |
| ▸ | BLK | P51451 | 1/20 | 0.30 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
| ▸ | STK3 | Q13188 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24094174 | 0.85 | ROCK1 (0.46) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL24610300 | 0.81 | JAK2 (0.34) | ROCK1SMN1; SMN2 | |
| SCHEMBL21217628 | 0.80 | ROCK1 (0.53) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL27338759 | 0.75 | SMN1; SMN2 (0.35) | ROCK1ROCK2SMN1; SMN2 | |
| SCHEMBL22967056 | 0.74 | ADORA2A (0.39) | ROCK1ROCK2SMN1; SMN2 | |
| SCHEMBL22967060 | 0.74 | ADORA2A (0.41) | SMN1; SMN2 | |
| SCHEMBL22967237 | 0.74 | CYP1A2 (0.43) | ROCK2SMN1; SMN2 | |
| SCHEMBL24094286 | 0.73 | IKBKE (0.36) | AURKBSMN1; SMN2 | |
| SCHEMBL24610309 | 0.72 | IKBKE (0.39) | AURKB | |
| SCHEMBL24094162 | 0.72 | CTDSP1 (0.39) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4026834-A1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | Redx Pharma Plc (GB) | 2022-07-13 | — | — | EP | disclosed |
| EP-3743420-B1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2021-12-15 | — | — | EP | disclosed |