Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | BLK | P51451 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | STK3 | Q13188 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 8/20 | 0.40 |
| ▸ | SLC2A3 | P11169 | 8/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24094185 | 0.85 | ROCK1 (0.33) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL24610300 | 0.83 | JAK2 (0.34) | ROCK1SMN1; SMN2 | |
| SCHEMBL24094175 | 0.81 | KMT2A (0.39) | KDM4EMEN1POLBMAPTKMT2A | |
| SCHEMBL24464157 | 0.81 | ROCK2 (0.66) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL22967018 | 0.80 | ROCK1 (0.71) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL24862408 | 0.79 | ROCK2 (0.58) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL24464184 | 0.79 | ROCK2 (0.53) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL24862354 | 0.79 | ROCK2 (0.69) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL24464196 | 0.79 | ROCK2 (0.68) | ROCK1ROCK2CLK2BLKCSNK2A1 | |
| SCHEMBL24862384 | 0.78 | ROCK2 (0.53) | ROCK1ROCK2CLK2BLKCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3743420-B1 | HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA PLC (GB) | 2021-12-15 | — | — | EP | disclosed |