Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.34 |
| ▸ | PRF1 | P14222 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21217607 | 0.79 | ROCK2 (0.49) | ROCK2ROCK1L3MBTL1 | |
| SCHEMBL24610300 | 0.79 | JAK2 (0.34) | SMN1; SMN2ROCK1HDAC3HDAC4HDAC1 | |
| SCHEMBL24094174 | 0.78 | ROCK1 (0.46) | SMN1; SMN2ROCK2ROCK1LMNAL3MBTL1 | |
| SCHEMBL21217738 | 0.75 | SMN1; SMN2 (0.47) | SMN1; SMN2PRF1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL24094185 | 0.75 | ROCK1 (0.33) | SMN1; SMN2ROCK2ROCK1 | |
| SCHEMBL22967056 | 0.73 | ADORA2A (0.39) | SMN1; SMN2ROCK2ROCK1LMNAL3MBTL1 | |
| SCHEMBL22967060 | 0.73 | ADORA2A (0.41) | SMN1; SMN2LMNAL3MBTL1ALDH1A1POLB | |
| SCHEMBL22967237 | 0.73 | CYP1A2 (0.43) | SMN1; SMN2ROCK2ALDH1A1KDM4EMAPT | |
| SCHEMBL21217821 | 0.73 | ROCK1 (0.60) | ROCK2ROCK1L3MBTL1 | |
| SCHEMBL21198526 | 0.72 | RXRA (0.41) | ROCK2PRF1ROCK1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240216386-A1 | MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | REDX PHARMA LIMITED (GB) | 2024-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240216386-A1 | MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE | ROCK2, ROCK1, RHOA | SMN1; SMN2 3144/4885ROCK2 1/4885PRF1 3983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.