Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.32 |
| ▸ | CDK2 | P24941 | 3/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25162856 | 0.88 | MERTK (0.34) | KDM4EHPGDALDH1A1HTR2AGAA | |
| SCHEMBL24096151 | 0.88 | MAOA (0.39) | KDM4EHPGDALDH1A1HTR2AGAA | |
| SCHEMBL24096167 | 0.84 | LRRK2 (0.36) | KDM4EHPGDALDH1A1HTR2AGAA | |
| SCHEMBL24096237 | 0.82 | GABRA1 (0.42) | KDM4EHPGDALDH1A1HTR2AGAA | |
| SCHEMBL24096279 | 0.82 | MAOA (0.34) | KDM4EHPGDALDH1A1HTR2AGAA | |
| SCHEMBL24096063 | 0.80 | GABRA1 (0.37) | KDM4EHPGDALDH1A1HTR2AGAA | |
| SCHEMBL24096217 | 0.80 | GABRA1 (0.38) | KDM4EHPGDALDH1A1HTR2AGAA | |
| SCHEMBL25163509 | 0.78 | MAOA (0.32) | HTR2ACCNA2CDK2MAOA | |
| SCHEMBL24096222 | 0.78 | PARP1 (0.43) | HTR2ACCNA2CDK2MAOA | |
| Hydrochloric Acid SCHEMBL20986872 | 0.77 | PARP1 (0.40) | KDM4EHPGDHTR2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021249904-A2 | AMINO-PYRIMIDINE CYCLO-AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2021-12-16 | — | — | WO | disclosed |