Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30272126 | 1.00 | GABRA1 (0.37) | GABRA1IL4I1GABRG2GABRB3GABRA5 | |
| SCHEMBL24096237 | 0.93 | GABRA1 (0.42) | GABRA1IRAK4HTR2ACCNA2CDK2 | |
| SCHEMBL30272086 | 0.93 | GABRA1 (0.42) | GABRA1IRAK4HTR2ACCNA2CDK2 | |
| SCHEMBL24096167 | 0.90 | LRRK2 (0.36) | GABRA1HTR2ACCNA2CDK2DRD2 | |
| SCHEMBL30272111 | 0.88 | GABRG2 (0.44) | IL4I1GABRG2GABRB3GABRA5KCNH2 | |
| SCHEMBL24096404 | 0.88 | GABRG2 (0.44) | IL4I1GABRG2GABRB3GABRA5KCNH2 | |
| SCHEMBL30272123 | 0.86 | MAOA (0.39) | GABRA1HTR2ACCNA2CDK2DRD2 | |
| SCHEMBL24096151 | 0.86 | MAOA (0.39) | GABRA1HTR2ACCNA2CDK2DRD2 | |
| SCHEMBL24096299 | 0.81 | CCNA2 (0.39) | GABRG2GABRB3GABRA5KCNH2CCNA2 | |
| SCHEMBL30272103 | 0.81 | CCNA2 (0.39) | GABRG2GABRB3GABRA5KCNH2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230123268-A1 | AMINO-PYRIMIDINE CYCLO-AMIDES | HOFFMANN-LA ROCHE INC. (US) | 2023-04-20 | — | — | US | disclosed |
| WO-2021249904-A2 | AMINO-PYRIMIDINE CYCLO-AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2021-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230123268-A1 | AMINO-PYRIMIDINE CYCLO-AMIDES | ATXN2, ATXN2L, ATXN10 | GABRA1 2627/4885IL4I1 163/4885GABRG2 3009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.