Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | TTK | P33981 | 2/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | TYK2 | P29597 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24096237 | 0.91 | GABRA1 (0.42) | MAOAGRM5IDH1HTR2AKDM4E | |
| SCHEMBL24096217 | 0.89 | GABRA1 (0.38) | MAOAIDH1HTR2AMAPK1KDM4E | |
| SCHEMBL24096167 | 0.88 | LRRK2 (0.36) | MAOAHTR2AKDM4EHPGDMEN1 | |
| SCHEMBL24096155 | 0.88 | KDM4E (0.32) | MAOAHTR2AKDM4EHPGDMEN1 | |
| SCHEMBL24096222 | 0.87 | PARP1 (0.43) | MAOAHTR2ACCNA2CDK2 | |
| SCHEMBL25162856 | 0.87 | MERTK (0.34) | MAOAHTR2APIM1TTKPIM2 | |
| SCHEMBL24096063 | 0.86 | GABRA1 (0.37) | MAOAHTR2AKDM4EHPGDMEN1 | |
| SCHEMBL24096279 | 0.85 | MAOA (0.34) | MAOAHTR2AKDM4EHPGDMEN1 | |
| Hydrochloric Acid SCHEMBL20986872 | 0.83 | PARP1 (0.40) | HTR2APIM1TTKPIM2MAPK1 | |
| Hydrochloric Acid SCHEMBL20986873 | 0.83 | PARP1 (0.40) | HTR2APIM1TTKPIM2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230123268-A1 | AMINO-PYRIMIDINE CYCLO-AMIDES | HOFFMANN-LA ROCHE INC. (US) | 2023-04-20 | — | — | US | disclosed |
| WO-2021249904-A2 | AMINO-PYRIMIDINE CYCLO-AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2021-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230123268-A1 | AMINO-PYRIMIDINE CYCLO-AMIDES | ATXN2, ATXN2L, ATXN10 | MAOA 244/4885GRM5 1650/4885IDH1 338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.