Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 17/20 | 0.60 |
| ▸ | ABL1 | P00519 | 13/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.60 |
| ▸ | PRKDC | P78527 | 10/20 | 0.60 |
| ▸ | EGFR | P00533 | 10/20 | 0.60 |
| ▸ | HCK | P08631 | 9/20 | 0.60 |
| ▸ | KDR | P35968 | 9/20 | 0.60 |
| ▸ | PI4KB | Q9UBF8 | 9/20 | 0.60 |
| ▸ | MTOR | P42345 | 8/20 | 0.60 |
| ▸ | EPHB4 | P54760 | 8/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.60 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | BACE1 | P56817 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12120525 | 0.87 | RET (0.67) | SRCABL1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL25069027 | 0.81 | SRC (0.76) | SRCABL1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL12436456 | 0.80 | SRC (0.76) | SRCABL1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL3630418 | 0.80 | SRC (0.76) | SRCABL1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL24096756 | 0.80 | BTK (0.55) | SRCABL1EGFRHCK | |
| SCHEMBL12120716 | 0.78 | AURKB (0.78) | SRCABL1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL24710409 | 0.78 | RET (0.82) | SRCABL1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL12120517 | 0.77 | SRC (0.64) | SRCABL1PIK3CDPIK3CAPIK3CG | |
| Trifluoroacetic Acid SCHEMBL30155338 | 0.77 | RET (0.77) | SRCABL1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL24710399 | 0.76 | RET (0.74) | SRCABL1PIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230210853-A1 | TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME | Halia Therapeutics, Inc. | 2023-07-06 | — | — | US | disclosed |
| US-20230210853-A1 | TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME | Halia Therapeutics, Inc. | 2023-07-06 | — | — | US | disclosed |
| US-20230203045-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. | 2023-06-29 | — | — | US | disclosed |
| US-20230203045-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. | 2023-06-29 | — | — | US | disclosed |
| WO-2021252488-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. (US) | 2021-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203045-A1 | INHIBITORS OF NEK7 KINASE | NEK7, NEK1, NEK5 | SRC 651/4885ABL1 2499/4885PIK3CD 1435/4885 |
| US-20230210853-A1 | TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME | NEK7, NLRP3, NOD1 | SRC 3388/4885ABL1 4556/4885PIK3CD 3373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.