Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 14/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 14/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 14/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 13/20 | 0.54 |
| ▸ | TSHR | P16473 | 13/20 | 0.54 |
| ▸ | USP2 | O75604 | 10/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.53 |
| ▸ | LMNA | P02545 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.51 |
| ▸ | GLA | P06280 | 3/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29890148 | 1.00 | APLNR (0.55) | APLNRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL16368537 | 0.79 | CYP1A2 (0.62) | APLNRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL319266 | 0.79 | APLNR (0.63) | APLNRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL28971693 | 0.79 | CLK4 (0.52) | CLK4MEN1KMT2AGAA | |
| SCHEMBL30855014 | 0.77 | MTNR1A (0.53) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL16177732 | 0.75 | CYP1A2 (0.69) | APLNRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3451889 | 0.75 | CYP1A2 (0.60) | APLNRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL22497892 | 0.75 | CYP1A2 (0.58) | APLNRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL30547197 | 0.75 | ERBB2 (0.54) | APLNRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL24033844 | 0.75 | CYP1A2 (0.55) | APLNRCYP1A2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250171425-A1 | USES OF CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | AMGEN INC. | 2025-05-29 | — | — | US | disclosed |
| CN-115697971-A | Cyclobutyldihydroquinoline sulfonamide compound | 美国安进公司 | 2023-02-03 | — | — | CN | disclosed |
| US-20220306604-A1 | CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2022-09-29 | — | — | US | disclosed |
| US-20210387978-A1 | CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2021-12-16 | — | — | US | disclosed |
| WO-2021252820-A1 | CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2021-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210387978-A1 | CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | TRPV1, SCN7A, TRPA1 | APLNR 2202/4885CYP1A2 1433/4885CYP3A4 1390/4885 |
| US-20250171425-A1 | USES OF CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | TRPV1, SCN7A, TRPA1 | APLNR 937/4885CYP1A2 1849/4885CYP3A4 2170/4885 |
| US-20220306604-A1 | CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS | TRPV1, SCN7A, TRPA1 | APLNR 2202/4885CYP1A2 1433/4885CYP3A4 1390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.