Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 6/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.33 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2409876 | 0.91 | HTR6 (0.34) | HTR6PTGDR2PLCG1HTR7 | |
| SCHEMBL2411542 | 0.91 | MET (0.41) | METCHRM5NFE2L2HTR6PTGDR2 | |
| SCHEMBL2412057 | 0.90 | PPME1 (0.34) | HTR6PTGDR2 | |
| SCHEMBL2410603 | 0.90 | HTR6 (0.33) | METCHRM5HTR6PTGDR2PLCG1 | |
| SCHEMBL2412131 | 0.89 | MET (0.40) | METCHRM5NFE2L2HTR6PTGDR2 | |
| SCHEMBL4999300 | 0.89 | MET (0.41) | METCHRM5NFE2L2HTR6PTGDR2 | |
| SCHEMBL2408012 | 0.87 | PTGDR2 (0.31) | HTR6PTGDR2PLCG1 | |
| SCHEMBL2409898 | 0.85 | MET (0.38) | METNFE2L2HTR6ELAVL1PLCG1 | |
| SCHEMBL2410118 | 0.84 | PPME1 (0.35) | HTR6PTGDR2 | |
| SCHEMBL2408074 | 0.82 | HTR6 (0.34) | HTR6PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364979-A1 | Pyrrole compounds | Takeda Pharmaceutical Company Limited (JP) | 2011-09-14 | — | — | EP | disclosed |
| EP-2114917-A2 | PYRROLE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008108380-A2 | PYRROLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-12 | — | — | WO | disclosed |