Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24100149 | 0.80 | HPGD (0.47) | HPGDTSHRALDH1A1HTTRAB9A | |
| SCHEMBL24100344 | 0.79 | RXRA (0.55) | HPGDTSHRALDH1A1KMT2ACNR2 | |
| SCHEMBL24100196 | 0.77 | PLA2G7 (0.48) | HPGDTSHRALDH1A1KMT2ACNR2 | |
| SCHEMBL24099835 | 0.75 | HPGD (0.55) | HPGDTSHRALDH1A1NPC1LMNA | |
| SCHEMBL24099614 | 0.75 | AR (0.48) | HPGDTSHRALDH1A1NPC1RAB9A | |
| SCHEMBL24100194 | 0.72 | AR (0.46) | HPGDTSHRALDH1A1RAB9AKMT2A | |
| SCHEMBL17689127 | 0.71 | HPGD (0.73) | HPGDTSHRALDH1A1TP53NPC1 | |
| SCHEMBL12569383 | 0.70 | HPGD (0.73) | HPGDTSHRALDH1A1TP53HTT | |
| SCHEMBL10242018 | 0.69 | HPGD (0.65) | HPGDTSHRALDH1A1TP53NPC1 | |
| SCHEMBL24100538 | 0.69 | HPGD (0.53) | HPGDTSHRALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3922247-A1 | 15-PGDH INHIBITOR | Kyorin Pharmaceutical Co., Ltd. (JP) | 2021-12-15 | — | — | EP | disclosed |