Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CCNK | O75909 | 2/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24101683 | 0.89 | MEN1 (0.61) | MAPTRAB9ANPC1ESR1POLB | |
| SCHEMBL24101688 | 0.85 | NPC1 (0.68) | MAPTRAB9ANPC1KDM4EPOLB | |
| SCHEMBL24101692 | 0.81 | MAPT (0.65) | MAPTRAB9ANPC1ESR1POLB | |
| SCHEMBL24101404 | 0.78 | CCNK (0.52) | MAPTRAB9ANPC1KDM4EESR1 | |
| SCHEMBL12050105 | 0.77 | MAPT (0.70) | MAPTRAB9ANPC1KDM4EPOLB | |
| SCHEMBL24101742 | 0.72 | CCNK (0.72) | MAPTRAB9ANPC1HTTSMN1; SMN2 | |
| SCHEMBL14625682 | 0.72 | MAPT (0.52) | MAPTRAB9ANPC1KDM4EPOLB | |
| SCHEMBL10466156 | 0.71 | ALOX5 (0.55) | MAPTRAB9ANPC1KDM4EPOLB | |
| SCHEMBL14069895 | 0.71 | MAPT (0.52) | MAPTKDM4EPOLBHTTALDH1A1 | |
| SCHEMBL12050079 | 0.70 | MAPT (0.59) | MAPTRAB9ANPC1POLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021249517-A1 | A MOLECULAR GLUE REGULATING CDK12-DDB1 INTERACTION TO TRIGGER CYCLIN K DEGRADATION | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-12-16 | — | — | WO | disclosed |