Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.55 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CCNK | O75909 | 2/20 | 0.51 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.51 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.51 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24101680 | 0.89 | MAPT (0.50) | MEN1KMT2AGAAMAPTCYP1A2 | |
| SCHEMBL24101692 | 0.87 | MAPT (0.65) | MEN1KMT2AGAAMAPTESR1 | |
| SCHEMBL24101742 | 0.83 | CCNK (0.72) | MEN1KMT2AGAAMAPTSLC12A2 | |
| SCHEMBL24101404 | 0.80 | CCNK (0.52) | MEN1KMT2AGAAMAPTESR1 | |
| SCHEMBL21501804 | 0.76 | GLS (0.70) | ESR1POLBALOX15HTTHSD17B10 | |
| SCHEMBL10977240 | 0.75 | MAPT (0.71) | MEN1KMT2AGAAMAPTSLC12A2 | |
| SCHEMBL20392510 | 0.74 | GLS (0.69) | GAAMAPTESR1POLBALOX15 | |
| SCHEMBL27446505 | 0.74 | MEN1 (0.60) | MEN1KMT2AGAAMAPTCYP1A2 | |
| SCHEMBL24101688 | 0.74 | NPC1 (0.68) | MEN1KMT2AGAAMAPTCYP1A2 | |
| SCHEMBL12050107 | 0.71 | MAPT (0.74) | MEN1KMT2AGAAMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021249517-A1 | A MOLECULAR GLUE REGULATING CDK12-DDB1 INTERACTION TO TRIGGER CYCLIN K DEGRADATION | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-12-16 | — | — | WO | disclosed |