Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2409198 | 0.85 | HDAC6 (0.52) | CFTRRIPK1RIPK3MAPTTP53 | |
| SCHEMBL2410246 | 0.83 | CFTR (0.63) | CFTRMAPTTP53DYRK1AMKNK1 | |
| SCHEMBL2408806 | 0.83 | CYP1A2 (0.44) | RIPK1RIPK3MAPTTP53DYRK1A | |
| SCHEMBL2410186 | 0.80 | MAPT (0.42) | POLBRIPK1RIPK3MAPTHDAC6 | |
| SCHEMBL2408774 | 0.79 | HPGD (0.41) | POLBMAPTHDAC6 | |
| SCHEMBL17052498 | 0.78 | HCAR1 (0.43) | CFTRMAPTFGFR1RPS6KA3 | |
| SCHEMBL2405739 | 0.78 | RPS6KA3 (0.53) | CFTRFGFR1RPS6KA3 | |
| SCHEMBL2408339 | 0.78 | RPS6KA3 (0.48) | POLBRPS6KA3PIK3CAMTOR | |
| SCHEMBL2408398 | 0.78 | PTPN11 (0.41) | RIPK1RIPK3MAPTTP53MKNK1 | |
| SCHEMBL2533237 | 0.75 | MKNK1 (0.36) | POLBRIPK1RIPK3MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011106168-A1 | PURINE COMPOUNDS FOR TREATING AUTOIMMUNE AND DEMYELINATING DISEASES | DCAM PHARMA INC (US) | 2011-09-01 | — | — | WO | claimed |
| WO-2011106168-A1 | PURINE COMPOUNDS FOR TREATING AUTOIMMUNE AND DEMYELINATING DISEASES | DCAM PHARMA INC (US) | 2011-09-01 | — | — | WO | disclosed |
| WO-2011106168-A1 | PURINE COMPOUNDS FOR TREATING AUTOIMMUNE AND DEMYELINATING DISEASES | DCAM PHARMA INC (US) | 2011-09-01 | — | — | WO | disclosed |